PDB entry 7lep

View 7lep on RCSB PDB site
Description: the composite lbd-tmd structure combined from all hippocampal ampar subtypes at 3.25 angstrom resolution
Deposited on 2021-01-14, released 2021-05-12
The last revision was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: EM
Resolution: 3.25 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mix of AMPAR subunits (GluA1, GluA3, and GluA4)
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LEP (0-413)
  • Chain 'B':
    Compound: Glutamate receptor 2
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9K0Z0 (0-423)
      • conflict (360)
  • Chain 'C':
    Compound: Mix of AMPAR subunits (GluA1, GluA3, and GluAX)
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LEP (0-412)
  • Chain 'D':
    Compound: Glutamate receptor 2
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9K0Z0 (0-423)
      • conflict (360)
  • Chain 'E':
    Compound: Protein cornichon homolog 2
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35089 (0-158)
      • conflict (98)
  • Chain 'F':
    Compound: Protein cornichon homolog 2
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35089 (0-158)
      • conflict (98)
  • Chain 'G':
    Compound: Voltage-dependent calcium channel gamma-8 subunit
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Voltage-dependent calcium channel gamma-8 subunit
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: XVD, ZK1, POV, C14, D10, OCT, D12

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lepA (A:)
taavttiaeapyvmlkknaaaaegnaayegycvalaaeiakhagaayaaaivadgkygar
daatkawngmvgelvygraaaaaapltitlvreevidfskpfmslgisimikkpqkskpg
vfsfldplayeiwmcivfayigvsvvlflvsrfsxxxxxxxxxxxnefgifnslwfslga
fmqqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspiesaedlakqt
eiaygtlaagstkeffrrskiavaakmwaymasaepsvfaattaagaarvrkakgkaaal
lestmneyieqrkpcdtmkvggnldskgygaatpkgsalrapvnlavlklaeqgaldklk
nkwwydkgecgaaaaaskaktsalslsnvagvfyilagglglamavaliefcyk

    Sequence, based on observed residues (ATOM records):
    >7lepA (A:)
taavttiaeapyvmlkknaaaaegnaayegycvalaaeiakhagaayaaaivadgkygar
daatkawngmvgelvygraaaaaapltitlvreevidfskpfmslgisimikkpqkskpg
vfsfldplayeiwmcivfayigvsvvlflvsrfsnefgifnslwfslgafmqqgcdispr
slsgrivggvwwfftliiissytanlaafltvermvspiesaedlakqteiaygtlaags
tkeffrrskiavaakmwaymasaepsvfaattaagaarvrkakgkaaallestmneyieq
rkpcdtmkvggnldskgygaatpkgsalrapvnlavlklaeqgaldklknkwwydkgecg
aaaaaskaktsalslsnvagvfyilagglglamavaliefcyk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7lepB (B:)
vvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygarda
dtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvf
sfldplayeiwmcivfayigvsvvlflvsrfspyewhteefedgretqssestnefgifn
slwfslgafmrqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspies
aedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrk
skgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlklne
eglldklknkwwydkgecgsgggdskektsalslsnvagvfyilvgglglamlvaliefc
yksr

    Sequence, based on observed residues (ATOM records):
    >7lepB (B:)
vvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygarda
dtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvf
sfldplayeiwmcivfayigvsvvlflvsrfsnefgifnslwfslgafmrqgcdisprsl
sgrivggvwwfftliiissytanlaafltvermvspiesaedlskqteiaygtldsgstk
effrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrk
pcdtmkvggnldskgygiatpkgsslgnavnlavlklneeglldklknkwwydkgecgsg
ggdskektsalslsnvagvfyilvgglglamlvaliefcyksr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7lepC (C:)
tavvttiledpyvmakknaaaaegnaayegycvalaaeiakhaayayaaaivadgkygar
daatkawngmvgelvygaadaaaapltitlvreevidfskpfmslgisimikkpqkskpg
vfsfldplayeiwmcivfayigvsvvlflvsrfsxxxxxxxxxxnefgifnslwfslgaf
mqqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspiesaedlakqte
iaygtlaagstkeffrrskiavaakmwaymasaepsvfaattaagaarvrkakgkaaall
estmneyieqrkpcdtmkvggnldskgygaatpkgsalrapvnlavlklaeqgaldklka
kwwydkgecgaaaaaskdktsalslsnvagvfyilagglglamavaliefcyk

    Sequence, based on observed residues (ATOM records):
    >7lepC (C:)
tavvttiledpyvmakknaaaaegnaayegycvalaaeiakhaayayaaaivadgkygar
daatkawngmvgelvygaadaaaapltitlvreevidfskpfmslgisimikkpqkskpg
vfsfldplayeiwmcivfayigvsvvlflvsrfsnefgifnslwfslgafmqqgcdispr
slsgrivggvwwfftliiissytanlaafltvermvspiesaedlakqteiaygtlaags
tkeffrrskiavaakmwaymasaepsvfaattaagaarvrkakgkaaallestmneyieq
rkpcdtmkvggnldskgygaatpkgsalrapvnlavlklaeqgaldklkakwwydkgecg
aaaaaskdktsalslsnvagvfyilagglglamavaliefcyk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7lepD (D:)
vvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygarda
dtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvf
sfldplayeiwmcivfayigvsvvlflvsrfspyewhteefedgretqssestnefgifn
slwfslgafmrqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspies
aedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrk
skgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlklne
eglldklknkwwydkgecgsgggdskektsalslsnvagvfyilvgglglamlvaliefc
yksr

    Sequence, based on observed residues (ATOM records):
    >7lepD (D:)
vvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygarda
dtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvf
sfldplayeiwmcivfayigvsvvlflvsrfsnefgifnslwfslgafmrqgcdisprsl
sgrivggvwwfftliiissytanlaafltvermvspiesaedlskqteiaygtldsgstk
effrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskgkyayllestmneyieqrk
pcdtmkvggnldskgygiatpkgsslgnavnlavlklneeglldklknkwwydkgecgsg
ggdskektsalslsnvagvfyilvgglglamlvaliefcyksr

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7lepE (E:)
aftfaafcymltlvlcasliffviwhiiafdelrtdfknpidqgnpararerlknieric
cllrklvvpeysihglfclmflcaaewvtlglnipllfthlwryfhrpadgsevmydavs
imnadilnycqkeswcklafyllsffyylysmvytlvsf

    Sequence, based on observed residues (ATOM records):
    >7lepE (E:)
aftfaafcymltlvlcasliffviwhiiafdelrtdarerlkniericcllrklvvpeys
ihglfclmflcaaewvtlglnipllfthlwryfhrpadgsesimnadilnycqkeswckl
afyllsffyylysmvytlvsf

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7lepF (F:)
aftfaafcymltlvlcasliffviwhiiafdelrtdfknpidqgnpararerlknieric
cllrklvvpeysihglfclmflcaaewvtlglnipllfthlwryfhrpadgsevmydavs
imnadilnycqkeswcklafyllsffyylysmvytlvsf

    Sequence, based on observed residues (ATOM records):
    >7lepF (F:)
aftfaafcymltlvlcasliffviwhiiafdelrtdarerlkniericcllrklvvpeys
ihglfclmflcaaewvtlglnipllfthlwryfhrpadgsesimnadilnycqkeswckl
afyllsffyylysmvytlvsf

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7lepG (G:)
vqvllttigafsafglmtiaistdywlytralicnttnltagddgpphrggsgssekkdp
gglthsglwriccleglkrgvcvkinhfpedtdydhdsaeyllrvvrassifpilsaill
llggvcvaasrvykskrniilgagilfvaaglsniigvivyisanagepgpkrdeekknh
ysygwsfyfgglsfilaevigvlavniyiersrea

    Sequence, based on observed residues (ATOM records):
    >7lepG (G:)
vqvllttigafsafglmtiaistdywlytrglthsglwriccleglkrgvcvkinhfaey
llrvvrassifpilsaillllggvcvaasrvykskrniilgagilfvaaglsniigvivy
isanagknhysygwsfyfgglsfilaevigvlavniyiersrea

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7lepH (H:)
vqvllttigafsafglmtiaistdywlytralicnttnltagddgpphrggsgssekkdp
gglthsglwriccleglkrgvcvkinhfpedtdydhdsaeyllrvvrassifpilsaill
llggvcvaasrvykskrniilgagilfvaaglsniigvivyisanagepgpkrdeekknh
ysygwsfyfgglsfilaevigvlavniyiersrea

    Sequence, based on observed residues (ATOM records):
    >7lepH (H:)
vqvllttigafsafglmtiaistdywlytrglthsglwriccleglkrgvcvkinhfaey
llrvvrassifpilsaillllggvcvaasrvykskrniilgagilfvaaglsniigvivy
isanagknhysygwsfyfgglsfilaevigvlavniyiersrea