PDB entry 7ld0

View 7ld0 on RCSB PDB site
Description: cryo-em structure of ligand-free human sarm1
Deposited on 2021-01-12, released 2021-03-10
The last revision was dated 2021-04-21, with a file datestamp of 2021-04-16.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: NAD(+) hydrolase SARM1
    Species: Homo sapiens [TaxId:9606]
    Gene: SARM1, KIAA0524, SAMD2, SARM
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ld0A (A:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0A (A:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ld0B (B:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0B (B:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7ld0C (C:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0C (C:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7ld0D (D:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0D (D:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7ld0E (E:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0E (E:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7ld0F (F:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0F (F:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7ld0G (G:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0G (G:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7ld0H (H:)
lavpgpdggggtgpwwaaggrgprevspgagtevqdaleralpelqqalsalkqaggara
vgaglaevfqlveeawllpavgrevaqglcdairldggldlllrllqapeletrvqaarl
leqilvaenrdrvariglgvilnlakerepvelarsvagilehmfkhseetcqrlvaagg
ldavlywcrrtdpallrhcalalgncalhggqavqrrmvekraaewlfplafskedellr
lhaclavavlatnkevereversgtlalveplvasldpgrfarclvdasdtsqgrgpddl
qrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigaiqslkrlvsystngtks
alakralrllgeevprpilpsvpswkeaevqtwlqqigfskycesfreqqvdgdlllrlt
eeelqtdlgmksgitrkrffreltelktfanystcdrsnladwlgsldprfrqytyglvs
cgldrsllhrvseqqlledcgihlgvhrariltaaremlhsplpctggkpsgdtpdvfis
yrrnsgsqlasllkvhlqlhgfsvfidvekleagkfedkliqsvmgarnfvlvlspgald
kcmqdhdckdwvhkeivtalscgknivpiidgfewpepqvlpedmqavltfngikwshey
qeatiekiirflqgrssrdssagsdtslegaapmgpt

    Sequence, based on observed residues (ATOM records):
    >7ld0H (H:)
vqdaleralpelqqalsalkqaggaravgaglaevfqlveeawllpavgrevaqglcdai
rldggldlllrllqapeletrvqaarlleqilvaenrdrvariglgvilnlakerepvel
arsvagilehmfkhseetcqrlvaaggldavlywcrrtdpallrhcalalgncalhggqa
vqrrmvekraaewlfplafskedellrlhaclavavlatnkevereversgtlalveplv
asldpgrfarrgpddlqrlvplldsnrleaqcigafylcaeaaikslqgktkvfsdigai
qslkrlvsystngtksalakralrllgeevprpilpsvpswkeaevqtwlqqigfskyce
sfreqqvdgdlllrlteeelqtdlgmksgitrkrffreltelktfanystcdrsnladwl
gsldprfrqytyglvscgldrsllhrvseqqlledcgihlgvhrariltaaremltpdvf
isyrrnsgsqlasllkvhlqlhgfsvfidvedkliqsvmgarnfvlvlspgaldkcdwvh
keivtalscgknivpiidgfewpqavltfngikwsheyqeatiekiirfl