PDB entry 7lci
View 7lci on RCSB PDB site
Description: PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
Class: membrane protein
Keywords: GPCR, small molecule agonist, MEMBRANE PROTEIN
Deposited on
2021-01-11, released
2021-01-20
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-05-19, with a file datestamp of
2021-05-14.
Experiment type: EM
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Species: Homo sapiens [TaxId:9606]
Gene: GNAS, GNAS1, GSP
Database cross-references and differences (RAF-indexed):
- Uniprot P63092 (Start-393)
- conflict (53)
- conflict (225)
- conflict (267)
- conflict (270)
- conflict (273)
- conflict (279)
- conflict (283-284)
- engineered mutation (365)
- Chain 'B':
Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Species: Homo sapiens [TaxId:9606]
Gene: GNB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d7lcib_ - Chain 'G':
Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Species: Homo sapiens [TaxId:9606]
Gene: GNG2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d7lcig_ - Chain 'R':
Compound: Glucagon-like peptide 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: GLP1R
Database cross-references and differences (RAF-indexed):
- Heterogens: UK4, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>7lciB (B:)
qseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
Sequence, based on observed residues (ATOM records): (download)
>7lciB (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn
- Chain 'G':
Sequence, based on SEQRES records: (download)
>7lciG (G:)
ntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr
Sequence, based on observed residues (ATOM records): (download)
>7lciG (G:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr
- Chain 'R':
No sequence available.