PDB entry 7lb4

View 7lb4 on RCSB PDB site
Description: Crystal structure of the second bromodomain (BD2) of human BRD3 bound to bromosporine
Class: gene regulation/inhibitor
Keywords: BET, ERK5, dual BRD-kinase inhibitor, GENE REGULATION, GENE REGULATION-INHIBITOR complex
Deposited on 2021-01-07, released 2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15059 (2-112)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7lb4a_
  • Chain 'B':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15059 (2-112)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7lb4b_
  • Heterogens: BMF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7lb4A (A:)
smgklsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkr
kmdgreypdaqgfaadvrlmfsncykynppdhevvamarklqdvfemrfakmp

    Sequence, based on observed residues (ATOM records): (download) 
    >7lb4A (A:)
sehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkrkmdgr
eypdaqgfaadvrlmfsncykynppdhevvamarklqdvfemrfakmp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7lb4B (B:)
smgklsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkr
kmdgreypdaqgfaadvrlmfsncykynppdhevvamarklqdvfemrfakmp

    Sequence, based on observed residues (ATOM records): (download) 
    >7lb4B (B:)
sehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkrkmdgr
eypdaqgfaadvrlmfsncykynppdhevvamarklqdvfemrfakmp