PDB entry 7l9g

View 7l9g on RCSB PDB site
Description: Crystal structure of the second bromodomain (BD2) of human BRD2 bound to BI2536
Class: transcription/transcription inhibitor
Keywords: BET, ERK5, dual BRD-kinase inhibitor, GENE REGULATION, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex
Deposited on 2021-01-04, released 2021-11-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-11-24, with a file datestamp of 2021-11-19.
Experiment type: XRAY
Resolution: 1.36 Å
R-factor: N/A
AEROSPACI score: 0.66 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440 (2-113)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7l9ga_
  • Heterogens: R78, EDO, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7l9gA (A:)
smgklseqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkr
kmenrdyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd

    Sequence, based on observed residues (ATOM records): (download) 
    >7l9gA (A:)
lseqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkmen
rdyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd