PDB entry 7l70

View 7l70 on RCSB PDB site
Description: the eukaryotic translation initiation factor 2b from homo sapiens in its apo form
Deposited on 2020-12-24, released 2021-03-24
The last revision was dated 2021-03-24, with a file datestamp of 2021-03-19.
Experiment type: EM
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7l70A (A:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynvslkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >7l70A (A:)
pplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwkaa
qikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisnin
itraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqg
lrrfafplslfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvnn
qihmhvtakeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrg
pevslghgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaag
aqihqsllcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeed

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7l70B (B:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynvslkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >7l70B (B:)
pplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwkaa
qikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisnin
itraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqg
lrrfafplslfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvnn
qihmhvtakeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrg
pevslghgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaag
aqihqsllcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeed

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7l70C (C:)
mhhhhhhgggsenlyfqspgsaakgselseriesfvetlkrgggprsseemaretlgllr
qiitdhrwsnagelmelirregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdes
dqqeslhklltsgglnedfsfhyaqlqsniieainellvelegtmeniaaqalehihsne
vimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmtdaaif
avmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqfpneed
sfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmsel
yhpddhvl

    Sequence, based on observed residues (ATOM records):
    >7l70C (C:)
gselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrr
mtaaqpsettvgnmvrrvlkiireeygrlhghyaqlqsniieainellvelegtmeniaa
qalehihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagie
ttvmtdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfk
lspqfpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnap
syiyrlmselyhpddhvl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7l70D (D:)
mhhhhhhgggsenlyfqspgsaakgselseriesfvetlkrgggprsseemaretlgllr
qiitdhrwsnagelmelirregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdes
dqqeslhklltsgglnedfsfhyaqlqsniieainellvelegtmeniaaqalehihsne
vimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmtdaaif
avmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqfpneed
sfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmsel
yhpddhvl

    Sequence, based on observed residues (ATOM records):
    >7l70D (D:)
gselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrr
mtaaqpsettvgnmvrrvlkiireeygrlhghyaqlqsniieainellvelegtmeniaa
qalehihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagie
ttvmtdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfk
lspqfpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnap
syiyrlmselyhpddhvl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7l70E (E:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >7l70E (E:)
vptrkdygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarc
iallralqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeits
vgsskreeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsril
qeawtegrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgah
allangsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqck
rgehvalanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlr

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7l70F (F:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >7l70F (F:)
dygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallr
alqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgssk
reeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawt
egrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallan
gsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehv
alanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlr

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7l70G (G:)
mhhhhhhgggsenlyfqsddkelieyfksqmkedpdmasavaairtlleflkrdkgetiq
glranltsaietlcgvdssvavssggelflrfislasleysdyskckkimiergelflrr
islsrnkiadlchtfikdgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkk
makalchlnvpvtvvldaavgyimekadlvivgaegvvenggiinkigtnqmavcakaqn
kpfyvvaesfkfvrlfplnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitl
lftdlgvltpsavsdeliklyl

    Sequence, based on observed residues (ATOM records):
    >7l70G (G:)
yfksqmkedpdmasavaairtlleflkrqglranltsaietlcgvdssvavssggelflr
fisskckkimiergelflrrislsrnkiadlchtfikdgatilthaysrvvlrvleaava
akkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyimekadlvivgaegvven
ggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvpdkfkyhpwvdytapsl
itllftdlgvltpsavsdeliklyl

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7l70H (H:)
mhhhhhhgggsenlyfqsddkelieyfksqmkedpdmasavaairtlleflkrdkgetiq
glranltsaietlcgvdssvavssggelflrfislasleysdyskckkimiergelflrr
islsrnkiadlchtfikdgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkk
makalchlnvpvtvvldaavgyimekadlvivgaegvvenggiinkigtnqmavcakaqn
kpfyvvaesfkfvrlfplnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitl
lftdlgvltpsavsdeliklyl

    Sequence, based on observed residues (ATOM records):
    >7l70H (H:)
kelieyfksqmkedpdmasavaairtlleflkrqglranltsaietlcgvdssvavssgg
elflrfiskimiergelflrrislsrnkiadlchtfikdgatilthaysrvvlrvleaav
aakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyimekadlvivgaegvve
nggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvpdkfkyhpwvdytaps
litllftdlgvltpsavsdeliklyl

  • Chain 'I':
    Sequence, based on SEQRES records:
    >7l70I (I:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >7l70I (I:)
mefqavvmavpkpllpvgnkpliwyplnllervgfeevivvttrdvqgtadslryiypkl
ktdvlvlscdlitdvalhevvdlfraydaslamlmrkgfigvdstgkrllfmaneadlde
elvikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqvr
cyvhimkeglcsrvstlglymeanrqvpkllsalc

  • Chain 'J':
    Sequence, based on SEQRES records:
    >7l70J (J:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >7l70J (J:)
mefqavvmavpkpllpvgnkpliwyplnllervgfeevivvttrdvqpdivcipddadmg
tadslryiypklktdvlvlscdlitdvalhevvdlfraydaslamlmrkgfigvdstgkr
llfmaneadldeelvikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirs
elipylvrkqfqvrcyvhimkeglcsrvstlglymeanrqvpkllsalc