PDB entry 7l27

View 7l27 on RCSB PDB site
Description: crystal structure of the catalytic domain of human pde3a
Deposited on 2020-12-16, released 2021-06-16
The last revision was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14432 (1-111)
      • expression tag (0)
      • linker (112-117)
    • Uniprot Q14432 (118-345)
      • linker (346-351)
    • Uniprot Q14432 (352-379)
  • Chain 'B':
    Compound: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14432 (1-End)
      • expression tag (0)
      • linker (112-117)
    • Uniprot Q14432 (118-345)
      • linker (346-351)
    • Uniprot Q14432 (352-379)
  • Chain 'C':
    Compound: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14432 (1-111)
      • expression tag (0)
      • linker (112-117)
    • Uniprot Q14432 (118-End)
      • linker (347-351)
      • linker (346)
    • Uniprot Q14432 (352-379)
  • Chain 'D':
    Compound: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14432 (1-111)
      • expression tag (0)
      • linker (112-117)
    • Uniprot Q14432 (118-345)
      • linker (346-351)
    • Uniprot Q14432 (352-379)
  • Heterogens: MN, MG, ACT, CA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7l27A (A:)
gkpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfea
fkipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstviggsggsyv
fsktynvtddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndr
svlenhhaaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfng
kvnddvgidwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeasl
glpispfmdrsapqlanlqesfishivgplcnsydsaglmpgkwveggsggsrrkiycqi
tqhllqnhkmwkkvieeeqr

    Sequence, based on observed residues (ATOM records):
    >7l27A (A:)
kpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfeaf
kipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstvgsyvfsktyn
vtddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrsvlenh
haaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngkvnddv
gidwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslglpisp
fmdrsapqlanlqesfishivgplcnsydsaglmpgkwvrkiycqitqhllqnhkmwkkv
iee

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7l27B (B:)
gkpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfea
fkipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstviggsggsyv
fsktynvtddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndr
svlenhhaaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfng
kvnddvgidwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeasl
glpispfmdrsapqlanlqesfishivgplcnsydsaglmpgkwveggsggsrrkiycqi
tqhllqnhkmwkkvieeeqr

    Sequence, based on observed residues (ATOM records):
    >7l27B (B:)
kpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfeaf
kipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstvigsyvfskty
dkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrsvlenhhaa
aawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngkvnddvgid
wtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslglpispfmd
rsapqlanlqesfishivgplcnsydsaglmpgkwvrkiycqitqhllqnhkmwkkviee
eq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7l27C (C:)
gkpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfea
fkipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstviggsggsyv
fsktynvtddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndr
svlenhhaaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfng
kvnddvgidwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeasl
glpispfmdrsapqlanlqesfishivgplcnsydsaglmpgkwveggsggsrrkiycqi
tqhllqnhkmwkkvieeeqr

    Sequence, based on observed residues (ATOM records):
    >7l27C (C:)
pilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfeafk
ipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstvggsyvfsktyn
vtddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrsvlenh
haaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngkvnddv
gidwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslglpisp
fmdrsapqlanlqesfishivgplcnsydsaglmpgkwvegrkiycqitqhllqnhkmwk
kvieee

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7l27D (D:)
gkpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfea
fkipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstviggsggsyv
fsktynvtddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndr
svlenhhaaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfng
kvnddvgidwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeasl
glpispfmdrsapqlanlqesfishivgplcnsydsaglmpgkwveggsggsrrkiycqi
tqhllqnhkmwkkvieeeqr

    Sequence, based on observed residues (ATOM records):
    >7l27D (D:)
kpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfeaf
kipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstviggsggsyvf
sktynvtddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrs
vlenhhaaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngk
vnddvgidwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslg
lpispfmdrsapqlanlqesfishivgplcnsydsaglmpgkwvrkiycqitqhllqnhk
mwkkvieeeq