PDB entry 7l26

View 7l26 on RCSB PDB site
Description: hpk1 in complex with compound 38
Class: transferase
Keywords: hpk1 hematopoietic progenitor kinase, inhibitor complex, transferase
Deposited on 2020-12-16, released 2021-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (0-286)
      • engineered mutation (163)
      • engineered mutation (183)
    Domains in SCOPe 2.08: d7l26a_
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (0-286)
      • engineered mutation (183)
    Domains in SCOPe 2.08: d7l26b_
  • Chain 'C':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (0-286)
      • engineered mutation (163)
      • engineered mutation (183)
    Domains in SCOPe 2.08: d7l26c_
  • Chain 'D':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (0-286)
      • engineered mutation (163)
      • engineered mutation (183)
    Domains in SCOPe 2.08: d7l26d_
  • Heterogens: XHM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7l26A (A:)
ifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaava
lkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaaf
hnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l26A (A:)
ifnrdprdhydllqrlggevfkardkvsgdlvalkmvkmepdddvstlqkeililktcrh
anivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhsq
kkihrdikganilindagevrladfaqigatlarrlafigtpywmapevaavalkgcyne
lcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikvt
ltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7l26B (B:)
ifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaava
lkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaaf
hnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l26B (B:)
ifnrdprdhydllqrlgevfkardkvsgdlvalkmvkmepdddvstlqkeililktcrha
nivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhsqk
kihrdikganilindagevrladfsaqigatlaigtpywmapevaavalkgcynelcdiw
slgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikvtltksp
kkrpsatkmlshqlvsqpglnrglildlldklknp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7l26C (C:)
ifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaava
lkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaaf
hnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l26C (C:)
ifnrdprdhydllqrlggevfkardkvsgdlvalkmvkmepdddvstlqkeililktcrh
anivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhsq
kkihrdikganilindagevrladfaqigatlarrlafigtpywmapevaavalkgcyne
lcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikvt
ltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7l26D (D:)
ifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaava
lkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaaf
hnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l26D (D:)
ifnrdprdhydllqrlgevfkardkvsgdlvalkmvkmepdddvstlqkeililktcrha
nivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhsqk
kihrdikganilindagevrladfsaqigrlafigtpywmapevaavalkgcynelcdiw
slgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikvtltksp
kkrpsatkmlshqlvsqpglnrglildlldklknp