PDB entry 7l25

View 7l25 on RCSB PDB site
Description: hpk1 in complex with compound 18
Deposited on 2020-12-16, released 2021-03-17
The last revision was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (Start-288)
      • engineered mutation (165)
      • engineered mutation (185)
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (0-End)
      • engineered mutation (165)
      • engineered mutation (185)
  • Heterogens: XHS, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7l25A (A:)
pdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeili
lktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgl
aylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaa
valkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsa
afhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records):
    >7l25A (A:)
difnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeilil
ktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgla
ylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaav
alkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaa
fhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7l25B (B:)
pdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeili
lktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgl
aylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaa
valkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsa
afhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records):
    >7l25B (B:)
pdifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeili
lktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgl
aylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaa
valkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsa
afhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklkn