PDB entry 7l24

View 7l24 on RCSB PDB site
Description: hpk1 in complex with compound 11
Class: transferase
Keywords: hpk1 hematopoietic progenitor kinase, inhibitor complex, transferase
Deposited on 2020-12-16, released 2021-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (0-End)
      • engineered mutation (164)
      • engineered mutation (184)
    Domains in SCOPe 2.08: d7l24a_
  • Chain 'B':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918 (0-End)
      • engineered mutation (184)
    Domains in SCOPe 2.08: d7l24b_
  • Chain 'C':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918
      • engineered mutation (164)
      • engineered mutation (184)
    Domains in SCOPe 2.08: d7l24c_
  • Chain 'D':
    Compound: mitogen-activated protein kinase kinase kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP4K1, HPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92918
      • engineered mutation (164)
      • engineered mutation (184)
    Domains in SCOPe 2.08: d7l24d_
  • Heterogens: XHV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7l24A (A:)
difnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeilil
ktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgla
ylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaav
alkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaa
fhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l24A (A:)
difnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeilil
ktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgla
ylhsqkkihrdikganilindagevrladfgisaqigatlarrlapywmapevaavalkg
cynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnf
ikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklkn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7l24B (B:)
difnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeilil
ktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgla
ylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaav
alkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaa
fhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l24B (B:)
difnrdprdhydllqrlgevfkardkvsgdlvalkmvkmepdddvstlqkeililktcrh
anivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhsq
kkihrdikganilindagevrladfgisaqigtpywmapevaavalkgcynelcdiwslg
itaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikvtltkspkkr
psatkmlshqlvsqpglnrglildlldklkn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7l24C (C:)
difnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeilil
ktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgla
ylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaav
alkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaa
fhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l24C (C:)
ifnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeililk
tcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglay
lhsqkkihrdikganilindagevrladfgisaqigaarrlafitpywmapevaavalkg
cynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnf
ikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklkn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7l24D (D:)
difnrdprdhydllqrlgggtygevfkardkvsgdlvalkmvkmepdddvstlqkeilil
ktcrhanivayhgsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqgla
ylhsqkkihrdikganilindagevrladfgisaqigatlarrlafigtpywmapevaav
alkgcynelcdiwslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaa
fhnfikvtltkspkkrpsatkmlshqlvsqpglnrglildlldklknp

    Sequence, based on observed residues (ATOM records): (download) 
    >7l24D (D:)
ifnrdprdhydllqrlvfkardkvsgdlvalkmvkmdvstlqkeililktcrhanivayh
gsylwlqklwicmefcgagslqdiyqvtgslselqisyvcrevlqglaylhsqkkihrdi
kganilindagevrladfgisaqigatlarrlafigtpywmapevaavalkgcynelcdi
wslgitaielaelqpplfdvhplrvlflmtksgyqpprlkekgkwsaafhnfikvtltks
pkkrpsatkmlshqlvsqpglnrglildlldklk