PDB entry 7l1v

View 7l1v on RCSB PDB site
Description: Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1
Class: membrane protein
Keywords: Class A GPCR, Orexin receptor 2, OX2R, membrane protein, Peptide agonist
Deposited on 2020-12-15, released 2021-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-17, with a file datestamp of 2021-02-12.
Experiment type: EM
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Engineered Guanine nucleotide-binding protein subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L1V (Start-243)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7l1vb_
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7l1vc_
  • Chain 'H':
    Compound: single-chain antibody Fv fragment (svFv16)
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L1V
    Domains in SCOPe 2.08: d7l1vh1, d7l1vh2
  • Chain 'R':
    Compound: Hypocretin receptor type 2
    Species: Homo sapiens [TaxId:9606]
    Gene: HCRTR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7l1vr_
  • Chain 'S':
    Compound: Synthetic nanobody 51 (Sb51)
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L1V
    Domains in SCOPe 2.08: d7l1vs_
  • Heterogens: XGD

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7l1vB (B:)
mghhhhhhhhseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtl
rghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgny
vacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdi
etgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdina
icffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagydd
fncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >7l1vB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7l1vC (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >7l1vC (C:)
ntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7l1vH (H:)
gsdvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgti
yyadtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttlt
vssggggsggggsggggsdivmtqatssvpvtpgesvsiscrssksllhsngntylywfl
qrpgqspqlliyrmsnlasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleyplt
fgagtklelk

    Sequence, based on observed residues (ATOM records): (download) 
    >7l1vH (H:)
dvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyy
adtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvs
gsdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqrpgqspqlliyrmsn
lasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfgagtklel

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >7l1vR (R:)
dykdddamgtkledsppcrnwssaselnetqepflnptdyddeeflrylwreylhpkeye
wvliagyiivfvvalignvlvcvavwknhhmrtvtnyfivnlsladvlvtitclpatlvv
ditetwffgqslckvipylqtvsvsvsvltlscialdrwyaichplmfkstakrarnsiv
iiwivsciimipqaivmecstvfpglankttlftvcderwggeiypkmyhicfflvtyma
plclmvlaylqifrklwcrqipgtsseikqirarrktarmlmvvllvfaicylpisilnv
lkrvfgmfahtedretvyawftfshwlvyansaanpiiynflsgkfreefkaafsccclg
vhhrhhhhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7l1vR (R:)
wvliagyiivfvvalignvlvcvavwknhhmrtvtnyfivnlsladvlvtitclpatlvv
ditetwffgqslckvipylqtvsvsvsvltlscialdrwyaichplmfkstakrarnsiv
iiwivsciimipqaivmecstvfpglankttlftvcderwggeiypkmyhicfflvtyma
plclmvlaylqifrklweikqirarrktarmlmvvllvfaicylpisilnvlkrvfgmfa
htedretvyawftfshwlvyansaanpiiynflsgkfreefkaa

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >7l1vS (S:)
gsssqvqlvesggglvqaggslrlscaasgfpvgrvmywyrqapgkerewvaaisshgdm
tayadsvkgrftisrdnakntvylqmnslkpedtavyycevyvgyfyhgqgtqvtvsa

    Sequence, based on observed residues (ATOM records): (download) 
    >7l1vS (S:)
vqlvesggglvqaggslrlscaasgfpvgrvmywyrqapgkerewvaaisshgdmtayad
svkgrftisrdnakntvylqmnslkpedtavyycevyvgyfyhgqgtqvtv