PDB entry 7l1a

View 7l1a on RCSB PDB site
Description: Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)
Class: transferase/inhibitor
Keywords: S-adenosylmethionine, SAM synthetase, enzyme mechanism, inhibitor, TRANSFERASE-INHIBITOR complex
Deposited on 2020-12-14, released 2021-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 1.25 Å
R-factor: N/A
AEROSPACI score: 0.7 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7l1aa1, d7l1aa2, d7l1aa3
  • Heterogens: MG, K, XE1, MTA, ALA, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7l1aA (A:)
mhhhhhhssgvdlgtenlyfqsmngqlngfheafieegtflftsesvgeghpdkicdqis
davldahlqqdpdakvacetvaktgmillageitsraavdyqkvvreavkhigyddsskg
fdyktcnvlvaleqqspdiaqgvhldrneedigagdqglmfgyatdeteecmpltivlah
klnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvqhdeevcldem
rdalkekvikavvpakyldedtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahg
ggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaigvshplsisifhygts
qkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >7l1aA (A:)
gtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsra
avdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagdq
glmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgav
lpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggp
qgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvl
vqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrta
ayghfgrdsfpwevpkklky