PDB entry 7l0n

View 7l0n on RCSB PDB site
Description: Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Class: viral protein/hydrolase
Keywords: COVID-19, SARS-CoV-2, variant RBD, viral protein-receptor complex, VIRAL PROTEIN, VIRAL PROTEIN-HYDROLASE complex
Deposited on 2020-12-11, released 2021-02-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 2.78 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Monoclonal antibody S309 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N
  • Chain 'B':
    Compound: Monoclonal antibody S309 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N (0-End)
    Domains in SCOPe 2.07: d7l0nb1, d7l0nb2
  • Chain 'C':
    Compound: Monoclonal antibody S309 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N (0-End)
  • Chain 'D':
    Compound: Monoclonal antibody S309 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N (0-End)
    Domains in SCOPe 2.07: d7l0nd1, d7l0nd2
  • Chain 'E':
    Compound: Angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7l0ne_
  • Chain 'F':
    Compound: Angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7l0nf_
  • Chain 'H':
    Compound: Monoclonal antibody S304 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N
  • Chain 'L':
    Compound: Monoclonal antibody S304 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N (0-End)
    Domains in SCOPe 2.07: d7l0nl1, d7l0nl2
  • Chain 'M':
    Compound: Monoclonal antibody S304 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N (0-End)
  • Chain 'N':
    Compound: Monoclonal antibody S304 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0N (0-End)
    Domains in SCOPe 2.07: d7l0nn1, d7l0nn2
  • Chain 'R':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (Start-203)
      • variant (111)
    Domains in SCOPe 2.07: d7l0nr_
  • Chain 'S':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (0-End)
      • variant (111)
    Domains in SCOPe 2.07: d7l0ns_
  • Heterogens: CL, SO4, NA, PG5, PG4, ZN, NAG, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >7l0nB (B:)
    eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
    drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nB (B:)
    eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
    drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrge
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >7l0nD (D:)
    eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
    drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nD (D:)
    eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
    drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrge
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >7l0nE (E:)
    stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
    laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
    qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
    ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
    igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
    glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
    iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
    llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
    dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
    rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nE (E:)
    stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
    laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgpglneima
    nsldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvd
    gydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispclpahllgdmwgrfw
    tnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltd
    pgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrng
    anegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftym
    lekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndysfiry
    ytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvg
    aknmnvrpllnyfeplftwlkdqnknsfvgwstdwspya
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >7l0nF (F:)
    stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
    laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
    qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
    ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
    igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
    glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
    iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
    llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
    dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
    rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nF (F:)
    stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
    laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
    qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
    ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
    igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
    glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
    iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
    llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
    dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
    rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspya
    

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >7l0nL (L:)
    diqmtqspsslsaavgdrvtitcrasqsigsylnwyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfaiyycqqsyvsptytfgpgtkvdikrtvaapsvfifp
    psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
    tlskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nL (L:)
    diqmtqspsslsaavgdrvtitcrasqsigsylnwyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfaiyycqqsyvsptytfgpgtkvdikrtvaapsvfifp
    psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
    tlskadyekhkvyacevthqglsspvtksfnrg
    

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    Sequence, based on SEQRES records: (download)
    >7l0nN (N:)
    diqmtqspsslsaavgdrvtitcrasqsigsylnwyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfaiyycqqsyvsptytfgpgtkvdikrtvaapsvfifp
    psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
    tlskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nN (N:)
    diqmtqspsslsaavgdrvtitcrasqsigsylnwyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfaiyycqqsyvsptytfgpgtkvdikrtvaapsvfifp
    psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
    tlskadyekhkvyacevthqglsspvtksfnrg
    

  • Chain 'R':
    Sequence, based on SEQRES records: (download)
    >7l0nR (R:)
    rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl
    ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsknldskvgg
    nynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqp
    yrvvvlsfellhapatvcgpkkst
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nR (R:)
    fpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkln
    dlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsknldskvggn
    ynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpy
    rvvvlsfellhapatvcgpkkst
    

  • Chain 'S':
    Sequence, based on SEQRES records: (download)
    >7l0nS (S:)
    rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl
    ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsknldskvgg
    nynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqp
    yrvvvlsfellhapatvcgpkkst
    

    Sequence, based on observed residues (ATOM records): (download)
    >7l0nS (S:)
    rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl
    ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsknldskvgg
    nynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqp
    yrvvvlsfellhapatvcgpk