PDB entry 7l0k

View 7l0k on RCSB PDB site
Description: Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM784 (3-(1-(3-methyl-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrrole-2-carboxamido)ethyl)-1H-pyrazole-5-carboxamide)
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Alpha-Beta Barrel, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2020-12-11, released 2021-05-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-19, with a file datestamp of 2021-05-14.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08210 (19-End)
      • expression tag (18)
    Domains in SCOPe 2.08: d7l0ka1, d7l0ka2
  • Chain 'B':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed):
  • Heterogens: XE7, FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7l0kA (A:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiisntttqindiks
fenkkggvsgaklkdistkficemynytnkqipiiasggifsgldalekieagasvcqly
sclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >7l0kA (A:)
pfesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhld
finpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinsc
gfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigrya
dyiainvsspntpglrdnqeagklkniilsvkeeidnleknnimndeflwfnttkkkplv
fvklapdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdist
kficemynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrel
nhllyqrgyynlkeaigrkhs

  • Chain 'B':
    No sequence available.