PDB entry 7l0g

View 7l0g on RCSB PDB site
Description: monobody 12vc1 bound to hras(g12c)
Deposited on 2020-12-11, released 2021-03-24
The last revision was dated 2021-05-26, with a file datestamp of 2021-05-21.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • engineered mutation (12)
  • Chain 'B':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • engineered mutation (12)
  • Chain 'C':
    Compound: Monobody 12VC1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0G (Start-96)
  • Chain 'D':
    Compound: Monobody 12VC1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0G (Start-96)
  • Chain 'E':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-End)
      • engineered mutation (12)
  • Chain 'F':
    Compound: Monobody 12VC1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0G (Start-96)
  • Chain 'G':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • engineered mutation (12)
  • Chain 'H':
    Compound: Monobody 12VC1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L0G (Start-96)
  • Heterogens: GSP, MG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7l0gA (A:)
smteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records):
    >7l0gA (A:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7l0gB (B:)
smteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records):
    >7l0gB (B:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7l0gC (C:)
gsvssvptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgsksta
tisglkpgvdytitvyargyskqgpykpspisinyrt

    Sequence, based on observed residues (ATOM records):
    >7l0gC (C:)
svptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgskstatisg
lkpgvdytitvyargyskqgpykpspisinyrt

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7l0gD (D:)
gsvssvptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgsksta
tisglkpgvdytitvyargyskqgpykpspisinyrt

    Sequence, based on observed residues (ATOM records):
    >7l0gD (D:)
svptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgskstatisg
lkpgvdytitvyargyskqgpykpspisinyrt

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7l0gE (E:)
smteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records):
    >7l0gE (E:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirq

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7l0gF (F:)
gsvssvptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgsksta
tisglkpgvdytitvyargyskqgpykpspisinyrt

    Sequence, based on observed residues (ATOM records):
    >7l0gF (F:)
svptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgskstatisg
lkpgvdytitvyargyskqgpykpspisinyrt

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7l0gG (G:)
smteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records):
    >7l0gG (G:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7l0gH (H:)
gsvssvptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgsksta
tisglkpgvdytitvyargyskqgpykpspisinyrt

    Sequence, based on observed residues (ATOM records):
    >7l0gH (H:)
vptklevvaatptslliswdapavtvffyvitygetghgvgafqafkvpgskstatisgl
kpgvdytitvyargyskqgpykpspisinyrt