PDB entry 7l06

View 7l06 on RCSB PDB site
Description: cryo-em structure of sars-cov-2 2p s ectodomain bound to two copies of domain-swapped antibody 2g12
Deposited on 2020-12-11, released 2020-12-30
The last revision was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: EM
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (0-1120)
      • conflict (959-960)
  • Chain 'B':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (0-1120)
      • conflict (959-960)
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (0-1120)
      • conflict (959-960)
  • Chain 'D':
    Compound: 2G12 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06 (0-225)
  • Chain 'E':
    Compound: 2G12 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06 (0-212)
  • Chain 'F':
    Compound: 2G12 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06
  • Chain 'G':
    Compound: 2G12 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06 (0-225)
  • Chain 'H':
    Compound: 2G12 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06 (0-225)
  • Chain 'K':
    Compound: 2G12 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06 (0-212)
  • Chain 'L':
    Compound: 2G12 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06
  • Chain 'M':
    Compound: 2G12 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7L06 (0-225)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7l06A (A:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpf
ndgvyfasteksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyh
knnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiysk
htpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayy
vgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesi
vrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptk
lndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvg
gnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyq
pyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfg
rdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaiha
dqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtqtnsprrars
vasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgds
tecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqil
pdpskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlppllt
demiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianq
fnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldp
peaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkg
yhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtq
rnfyepqiittdntfvsgncdvvigivnntvydplqpelds

    Sequence, based on observed residues (ATOM records):
    >7l06A (A:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihdnpvlpfndgvyfaste
ksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvnctfeyvsfknlr
efvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhaayyv
gylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesiv
rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl
ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskgny
nylyrkpferdiyfplqsygfqptnvgyqpyrvvvlsfellhapatvcgpkkstnlvknk
cvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsv
itpgtntsnqvavlyqdvnctevnvfqtragcligaehvnnsyecdipigagicasyqts
qsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstec
snlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdp
skpskrsfiedllfnkvtkfngltvlpplltdemiaqytsallagtitsgwtfgagaalq
ipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn
aqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqlira
aeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknf
ttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnn
tvydplqpelds

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7l06B (B:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpf
ndgvyfasteksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyh
knnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiysk
htpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayy
vgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesi
vrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptk
lndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvg
gnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyq
pyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfg
rdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaiha
dqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtqtnsprrars
vasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgds
tecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqil
pdpskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlppllt
demiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianq
fnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldp
peaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkg
yhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtq
rnfyepqiittdntfvsgncdvvigivnntvydplqpelds

    Sequence, based on observed residues (ATOM records):
    >7l06B (B:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihdnpvlpfndgvyfaste
ksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvnctfeyvsfknlr
efvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhaayyv
gylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesiv
rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl
ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskgny
nylyrkpferdiyfplqsygfqptnvgyqpyrvvvlsfellhapatvcgpkkstnlvknk
cvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsv
itpgtntsnqvavlyqdvnctevnvfqtragcligaehvnnsyecdipigagicasyqts
qsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstec
snlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdp
skpskrsfiedllfnkvtkfngltvlpplltdemiaqytsallagtitsgwtfgagaalq
ipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn
aqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqlira
aeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknf
ttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnn
tvydplqpelds

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7l06C (C:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpf
ndgvyfasteksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyh
knnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiysk
htpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayy
vgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesi
vrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptk
lndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvg
gnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyq
pyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfg
rdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaiha
dqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtqtnsprrars
vasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgds
tecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqil
pdpskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlppllt
demiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianq
fnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldp
peaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkg
yhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtq
rnfyepqiittdntfvsgncdvvigivnntvydplqpelds

    Sequence, based on observed residues (ATOM records):
    >7l06C (C:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihdnpvlpfndgvyfaste
ksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvnctfeyvsfknlr
efvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhaayyv
gylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesiv
rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl
ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskgny
nylyrkpferdiyfplqsygfqptnvgyqpyrvvvlsfellhapatvcgpkkstnlvknk
cvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsv
itpgtntsnqvavlyqdvnctevnvfqtragcligaehvnnsyecdipigagicasyqts
qsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstec
snlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdp
skpskrsfiedllfnkvtkfngltvlpplltdemiaqytsallagtitsgwtfgagaalq
ipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn
aqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqlira
aeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknf
ttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnn
tvydplqpelds

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7l06D (D:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsxxxxxxxxgtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

    Sequence, based on observed residues (ATOM records):
    >7l06D (D:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >7l06E (E:)
dvvmtqspstlsasvgdtititcrasqsietwlawyqqkpgkapklliykastlktgvps
rfsgsgsgteftltisglqfddfatyhcqhyagysatfgqgtrveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7l06F (F:)
dvvmtqspstlsasvgdtititcrasqsietwlawyqqkpgkapklliykastlktgvps
rfsgsgsgteftltisglqfddfatyhcqhyagysatfgqgtrveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

    Sequence, based on observed residues (ATOM records):
    >7l06F (F:)
vvmtqspstlsasvgdtititcrasqsietwlawyqqkpgkapklliykastlktgvpsr
fsgsgsgteftltisglqfddfatyhcqhyagysatfgqgtrveikrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
skadyekhkvyacevthqglsspvtksfnrg

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7l06G (G:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsxxxxxxxxgtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

    Sequence, based on observed residues (ATOM records):
    >7l06G (G:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7l06H (H:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsxxxxxxxxgtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

    Sequence, based on observed residues (ATOM records):
    >7l06H (H:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records:
    >7l06K (K:)
dvvmtqspstlsasvgdtititcrasqsietwlawyqqkpgkapklliykastlktgvps
rfsgsgsgteftltisglqfddfatyhcqhyagysatfgqgtrveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'L':
    Sequence, based on SEQRES records:
    >7l06L (L:)
dvvmtqspstlsasvgdtititcrasqsietwlawyqqkpgkapklliykastlktgvps
rfsgsgsgteftltisglqfddfatyhcqhyagysatfgqgtrveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

    Sequence, based on observed residues (ATOM records):
    >7l06L (L:)
vvmtqspstlsasvgdtititcrasqsietwlawyqqkpgkapklliykastlktgvpsr
fsgsgsgteftltisglqfddfatyhcqhyagysatfgqgtrveikrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
skadyekhkvyacevthqglsspvtksfnrg

  • Chain 'M':
    Sequence, based on SEQRES records:
    >7l06M (M:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsxxxxxxxxgtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

    Sequence, based on observed residues (ATOM records):
    >7l06M (M:)
evqlvesggglvkaggslilscgvsnfrisahtmnwvrrvpggglewvasistsstyrdy
adavkgrftvsrddledfvylqmhkmrvedtaiyycarkgsdrlsdndpfdawgpgtvvt
vspastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk