PDB entry 7kzb

View 7kzb on RCSB PDB site
Description: Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Class: VIRAL PROTEIN/Immune System
Keywords: COVID19, SARS-CoV2, antibody, ANTIVIRAL PROTEIN, VIRAL PROTEIN-Immune System complex
Deposited on 2020-12-10, released 2021-02-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 2.83 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab heavy chain of CR3022-B6 antibody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KZB
  • Chain 'B':
    Compound: Fab light chain of CR3022-B6 antibody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KZB (Start-213)
    Domains in SCOPe 2.08: d7kzbb1, d7kzbb2
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7kzbc_
  • Chain 'H':
    Compound: Fab heavy chain of CR3014-C8 antibody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KZB (0-End)
    Domains in SCOPe 2.08: d7kzbh_
  • Chain 'L':
    Compound: Fab light chain of CR3014-C8 antibody
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KZB (0-213)
    Domains in SCOPe 2.08: d7kzbl1, d7kzbl2
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7kzbB (B:)
diqmtqspsslsasvgdrvtitcrasqsiysalnwyqqkpgkapklliyaasalqsgvps
rfsgsgsgtdftltisslqpedfatyycqqtdihpytfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7kzbB (B:)
iqmtqspsslsasvgdrvtitcrasqsiysalnwyqklliyaasalqsgvpsrfsgsgsg
tdftltisslqpedfatyycqqtdihpytfgqgtkveikrtvaapsvfifppsdeqlasv
vcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltlskadyekhkvy
acevthqglsspvtksfnrgec

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7kzbC (C:)
tnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcf
tnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynyl
yrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvv
lsfellhapatvcgpkgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7kzbC (C:)
nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcft
nvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynyly
rlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvl
sfellhapatvc

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7kzbH (H:)
evqlvesggglvqpggslrlscaasgftfsdhymdwvrqapgkglewvgrtrnkansytt
eyaasvkgrftisrddsknslylqmnslktedtavyycargispfyfdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7kzbH (H:)
evqlvesggglvqpggslrlscaasgftfsdhymdwvrqapgkglewvgrtrnkansytt
eyaasvkgrftisrddsknslylqmnslktedtavyycargispfyfdywgqgtlvtvss
astkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7kzbL (L:)
diqmtqspsslsasvgdrvtitcrasqyiydslnwyqqkpgkapklliydssylqsgvps
rfsgsgsgtdftltisslqpedfatyycqqswdtpvtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec