PDB entry 7kvk

View 7kvk on RCSB PDB site
Description: Human CYP3A4 bound to an inhibitor
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: CYP3A4, inhibitor, complex, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2020-11-28, released 2021-01-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-02-03, with a file datestamp of 2021-01-29.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP3A4, CYP3A3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08684
      • engineered mutation (400)
      • engineered mutation (403)
    Domains in SCOPe 2.07: d7kvka_
  • Chain 'B':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP3A4, CYP3A3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08684
      • engineered mutation (400)
      • engineered mutation (403)
    Domains in SCOPe 2.07: d7kvkb_
  • Heterogens: X7J, HEM, SO4, GOL, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kvkA (A:)
maylygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqp
vlaitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsg
klkemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpq
dpfventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesr
ledtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimye
lathpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkd
veingmfipkgvvvmipsyalhrdpkywtepekflperfsaknadnidpyiytpfgsgpr
ncigmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtv
sgahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7kvkA (A:)
thshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitd
pdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemv
piiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfven
tkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrhrvdfl
qlmidsqnshkalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeida
vlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmip
syalhrdpkywtepekflperfsaknadnidpyiytpfgsgprncigmrfalmnmklali
rvlqnfsfkpcketqiplklslggllqpekpvvlkvesr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7kvkB (B:)
maylygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqp
vlaitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsg
klkemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpq
dpfventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesr
ledtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimye
lathpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkd
veingmfipkgvvvmipsyalhrdpkywtepekflperfsaknadnidpyiytpfgsgpr
ncigmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtv
sgahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7kvkB (B:)
shglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpd
miktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpi
iaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidspqdpfventkkll
rfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmvdflqlmidsqnals
dlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavlpnkapptydtvl
qmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsyalhrdpkywtep
ekflperfsaknadnidpyiytpfgsgprncigmrfalmnmklalirvlqnfsfkpcket
qiplklslggllqpekpvvlkvesr