PDB entry 7kp6

View 7kp6 on RCSB PDB site
Description: Structure of Ack1 kinase in complex with a selective inhibitor
Class: transferase/inhibitor
Keywords: protein-inhibitor complex, tyrosine kinase, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Deposited on 2020-11-10, released 2022-02-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-02-09, with a file datestamp of 2022-02-04.
Experiment type: XRAY
Resolution: 1.79 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activated CDC42 kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TNK2, ACK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07912 (5-286)
      • expression tag (0-4)
    Domains in SCOPe 2.08: d7kp6a_
  • Chain 'B':
    Compound: Activated CDC42 kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TNK2, ACK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07912 (5-286)
      • expression tag (0-4)
    Domains in SCOPe 2.08: d7kp6b_
  • Heterogens: WTP, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kp6A (A:)
gamgsgegplqsltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdv
lsqpeamddfirevnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghf
llgtlsryavqvaegmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhy
vmqehrkvpfawcapeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkid
kegerlprpedcpqdiynvmvqcwahkpedrptfvalrdflleaqpt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kp6A (A:)
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclpeamddfirevnamhs
ldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqvaegmgyl
eskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfawcapeslk
trtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcpqdiynv
mvqcwahkpedrptfvalrdflleaqpt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7kp6B (B:)
gamgsgegplqsltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdv
lsqpeamddfirevnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghf
llgtlsryavqvaegmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhy
vmqehrkvpfawcapeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkid
kegerlprpedcpqdiynvmvqcwahkpedrptfvalrdflleaqpt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kp6B (B:)
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclqpeamddfirevnamh
sldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqvaegmgy
leskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmkvpfawcapeslktrt
fshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcpqdiynvmvq
cwahkpedrptfvalrdflleaqpt