PDB entry 7kmf

View 7kmf on RCSB PDB site
Description: sugar phosphate activation of the stress sensor eif2b
Deposited on 2020-11-02, released 2021-07-14
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: EM
Resolution: 2.91 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49770 (16-366)
      • initiating methionine (0)
      • expression tag (1-15)
  • Chain 'D':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49770 (16-366)
      • initiating methionine (0)
      • expression tag (1-15)
  • Chain 'E':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14232 (0-304)
      • expression tag (305-376)
  • Chain 'H':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14232 (0-304)
      • expression tag (305-376)
  • Chain 'I':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: F6P, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7kmfB (B:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >7kmfB (B:)
pplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwkaa
qikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisnin
itraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqg
lrrfafplslfvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvnnqihmhv
takeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslg
hgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqs
llcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdge

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7kmfC (C:)
mdykddddkenlyfqsmpgsaakgselseriesfvetlkrgggprsseemaretlgllrq
iitdhrwsnagelmelirregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdesd
qqeslhklltsgglnedfsfhyaqlqsniieainellvelegtmeniaaqalehihsnev
imtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmtdaaifa
vmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqfpneeds
fhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmsely
hpddhvl

    Sequence, based on observed residues (ATOM records):
    >7kmfC (C:)
selseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrrm
taaqpsettvgnmvrrvlkiireeygrlhyaqlqsniieainellvelegtmeniaaqal
ehihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettv
mtdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklsp
qfpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyi
yrlmselyhpddhvl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7kmfD (D:)
mdykddddkenlyfqsmpgsaakgselseriesfvetlkrgggprsseemaretlgllrq
iitdhrwsnagelmelirregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdesd
qqeslhklltsgglnedfsfhyaqlqsniieainellvelegtmeniaaqalehihsnev
imtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmtdaaifa
vmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqfpneeds
fhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmsely
hpddhvl

    Sequence, based on observed residues (ATOM records):
    >7kmfD (D:)
selseriesfvetlkrggrsseemaretlgllrqiitdhrwsnagelmelirregrrmta
aqpsettvgnmvrrvlkiireeygrlhhyaqlqsniieainellvelegtmeniaaqale
hihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvm
tdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspq
fpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiy
rlmselyhpddhvl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7kmfE (E:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >7kmfE (E:)
lfshlpqyssltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdyt
tlsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsreeeakselraaidryv
qekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvvvdsrpwle
grhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgtaqlalvar
ahnvpvlvccetykfcervqtdafvsnelddpddlqckrhvalanwqnhaslrllnlvyd
vtppelvdlvitelgmipcssvpvvlrvks

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7kmfF (F:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >7kmfF (F:)
lfshlpqysltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdytt
lsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgseeakselraaidryvqek
ivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvvvdsrpwlegrh
tlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgtaqlalvarahn
vpvlvccetykfcervqtdafvsnelddpddlqckvalanwqnhaslrllnlvydvtppe
lvdlvitelgmipcssvpvvlrvks

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7kmfG (G:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklylggenlyfqaedkgggsggggsggggsasqgglndifeaqkiewheggggsggggs
ggggsgrdqdykddddk

    Sequence, based on observed residues (ATOM records):
    >7kmfG (G:)
dkelieyfksqmkedpdmasavaairtlleflkriqglranltsaietlcgvdssvavss
ggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfikdgatilt
haysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyim
ekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvp
dkfkykalkeehpwvdytapslitllftdlgvltpsavsdeliklyl

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7kmfH (H:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklylggenlyfqaedkgggsggggsggggsasqgglndifeaqkiewheggggsggggs
ggggsgrdqdykddddk

    Sequence, based on observed residues (ATOM records):
    >7kmfH (H:)
dkelieyfksqmkedpdmasavaairtlleflkrtiqglranltsaietlcgvdssvavs
sggelflrfislaskckkimiergelflrrislsrnkiadlchtfikdgatilthaysrv
vlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyimekadlv
ivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvpdkfkyk
alkeehpwvdytapslitllftdlgvltpsavsdelikly

  • Chain 'I':
    Sequence, based on SEQRES records:
    >7kmfI (I:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >7kmfI (I:)
pplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwkaa
qikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisnin
itraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqg
lrrfafplslfqvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvnnqihmh
vtakeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevsl
ghgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihq
sllcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefs

  • Chain 'J':
    Sequence, based on SEQRES records:
    >7kmfJ (J:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >7kmfJ (J:)
mefqavvmaiwyplnllervgfeevivvivcipadslryiypklktdvlvlscdlitdva
lhevvdlfraydaslamlmrrdfigvdstgkrllfmaadldeelvikgsilqkhprirfh
tglvdahlyclkkyivdfselipylvrkqfassqsldiysfi

  • Chain 'K':
    Sequence, based on SEQRES records:
    >7kmfK (K:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >7kmfK (K:)
mefqavvmaiwyplnllefeevivivciadslryiypklktdvlvlscdlitdvalhevv
dlfraydaslamlmrrdfigvdstgkrllfmaneadldeelvikgsilqkhprirfhtgl
vdahlyclkkyivdflmeselipylvrkqfassqksldiysfi