PDB entry 7kkn

View 7kkn on RCSB PDB site
Description: structure of the catalytic domain of tankyrase 1 in complex with talazoparib
Deposited on 2020-10-27, released 2021-01-06
The last revision was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: XRAY
Resolution: 1.48 Å
R-factor: N/A
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Poly [ADP-ribose] polymerase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Poly [ADP-ribose] polymerase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Poly [ADP-ribose] polymerase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, 2YQ, MES, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7kknA (A:)
gsqgtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrer
fchrqkevseenhnhhnermlfhgspfinaiihkgfderhayiggmfgagiyfaenssks
nqyvygigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigr
psvnglayaeyviyrgeqaypeylityqimkpe

    Sequence, based on observed residues (ATOM records):
    >7kknA (A:)
gtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrerfch
rqkevseenhnhhnermlfhgspfinaiihkgfderhaggmfgagiyfaenssksnqyvy
gigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigrpsvng
layaeyviyrgeqaypeylityqimkp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7kknB (B:)
gsqgtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrer
fchrqkevseenhnhhnermlfhgspfinaiihkgfderhayiggmfgagiyfaenssks
nqyvygigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigr
psvnglayaeyviyrgeqaypeylityqimkpe

    Sequence, based on observed residues (ATOM records):
    >7kknB (B:)
gtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrerfch
rqkevseenhnhhnermlfhgspfinaiihkgfderhayiggmfgagiyfaenssksnqy
vygigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigrpsv
nglayaeyviyrgeqaypeylityqimkpe

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7kknC (C:)
gsqgtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrer
fchrqkevseenhnhhnermlfhgspfinaiihkgfderhayiggmfgagiyfaenssks
nqyvygigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigr
psvnglayaeyviyrgeqaypeylityqimkpe

    Sequence, based on observed residues (ATOM records):
    >7kknC (C:)
gtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrerfch
rqkevseenhnhhnermlfhgspfinaiihkgfderhayiggmfgagiyfaenssksnqy
vygigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigrpsv
layaeyviyrgeqaypeylityqimkp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7kknD (D:)
gsqgtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrer
fchrqkevseenhnhhnermlfhgspfinaiihkgfderhayiggmfgagiyfaenssks
nqyvygigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigr
psvnglayaeyviyrgeqaypeylityqimkpe

    Sequence, based on observed residues (ATOM records):
    >7kknD (D:)
gtilldlapedkeyqsveeemqstirehrdggnaggifnrynviriqkvvnkklrerfch
rqkevseenhnhhnermlfhgspfinaiihkgfderhayiggmfgagiyfaenssksnqy
vygigggtgcpthkdrscyichrqmlfcrvtlgksflqfstmkmahappghhsvigrpsv
nglayaeyviyrgeqaypeylityqimkpe