PDB entry 7kk6

View 7kk6 on RCSB PDB site
Description: Structure of the catalytic domain of PARP1 in complex with veliparib
Class: transferase
Keywords: parp1, transferase
Deposited on 2020-10-27, released 2021-01-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-01-06, with a file datestamp of 2021-01-01.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09874 (2-351)
      • expression tag (1)
    Domains in SCOPe 2.07: d7kk6a1, d7kk6a2, d7kk6a3
  • Chain 'B':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7kk6b1, d7kk6b2
  • Heterogens: 78P, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kk6A (A:)
gsksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqa
vsqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllr
ggsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifki
eregecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfad
mvsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdps
anisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kk6A (A:)
sksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqav
sqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllrg
gsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifkie
regecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadm
vsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsa
nisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7kk6B (B:)
gsksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqa
vsqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllr
ggsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifki
eregecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfad
mvsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdps
anisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kk6B (B:)
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllrgg
sddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifkier
egecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmv
sksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsan
isldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfk