PDB entry 7kk3

View 7kk3 on RCSB PDB site
Description: Structure of the catalytic domain of PARP1 in complex with talazoparib
Class: transferase
Keywords: parp1, transferase
Deposited on 2020-10-27, released 2021-01-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7kk3a1, d7kk3a2
  • Chain 'B':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7kk3b1, d7kk3b2
  • Chain 'C':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09874 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.08: d7kk3c1, d7kk3c2, d7kk3c3
  • Chain 'D':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7kk3d1, d7kk3d2
  • Heterogens: 2YQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kk3A (A:)
gsksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqa
vsqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllr
ggsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifki
eregecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfad
mvsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdps
anisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kk3A (A:)
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qdsqildlsnrfytliphdfkppnnadsvqakvemldnlldievaysllrgskdpidvny
eklktdikvvdrdseeaeiirkyvknthatthnaydlevidifkieregecqrykpfkql
hnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanychtsqgd
piglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvplgtg
issgvndtsllyneyivydiaqvnlkyllklkfnfk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7kk3B (B:)
gsksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqa
vsqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllr
ggsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifki
eregecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfad
mvsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdps
anisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kk3B (B:)
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qgssdsqildlsnrfytliphdfkkppllnnadsvqakvemldnlldievaysllrgssk
dpidvnyeklktdikvvdrdseeaeiirkyvkntaydlevidifkieregecqrykpfkq
lhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanychtsqg
dpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvplgt
gissgvndtsllyneyivydiaqvnlkyllklkfnfk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7kk3C (C:)
gsksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqa
vsqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllr
ggsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifki
eregecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfad
mvsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdps
anisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kk3C (C:)
sksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqav
sqgssdsqildlsnrfytliphdpllnnadsvqakvemldnlldievaysllrggsddss
kdpidvnyeklktdikvvdrdseeaeiirkyvknthnaydlevidifkieregecqrykp
fkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanycht
sqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvp
lgtgissgvndtsllyneyivydiaqvnlkyllklkfnfk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7kk3D (D:)
gsksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqa
vsqgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllr
ggsddsskdpidvnyeklktdikvvdrdseeaeiirkyvknthatthnaydlevidifki
eregecqrykpfkqlhnrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfad
mvsksanychtsqgdpiglillgevalgnmyelkhashisklpkgkhsvkglgkttpdps
anisldgvdvplgtgissgvndtsllyneyivydiaqvnlkyllklkfnfkt

    Sequence, based on observed residues (ATOM records): (download) 
    >7kk3D (D:)
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qildlsnrfytliphdppllnnadsvqakvemldnlldievaysllrggdpidvnyeklk
tdikvvdrdseeaeiirkyvknthnaydlevidifkieregecqrykpfkqlhnrrllwh
gsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanychtsqgdpiglillg
evalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvplgtgissgvndt
sllyneyivydiaqvnlkyllklkfnfk