PDB entry 7kid

View 7kid on RCSB PDB site
Description: prmt5:mep50 complexed with 5,5-bicyclic inhibitor compound 72
Deposited on 2020-10-23, released 2021-04-21
The last revision was dated 2021-04-21, with a file datestamp of 2021-04-16.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein arginine N-methyltransferase 5
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT5, HRMT1L5, IBP72, JBP1, SKB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Methylosome protein 50
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR77, MEP50, WD45, HKMT1069, Nbla10071
    Database cross-references and differences (RAF-indexed):
  • Heterogens: WFV, EDO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7kidA (A:)
mdykddddkaamavggaggsrvssgrdlncvpeiadtlgavakqgfdflcmpvfhprfkr
efiqepaknrpgpqtrsdlllsgrdwntlivgklspwirpdskvekirrnseaamlqeln
fgaylglpafllplnqedntnlarvltnhihtghhssmfwmrvplvapedlrddiienap
tthteeysgeektwmwwhnfrtlcdyskriavaleigadlpsnhvidrwlgepikaailp
tsifltnkkgfpvlskmhqrlifrllklevqfiitgtnhhsekefcsylqyleylsqnrp
ppnayelfakgyedylqsplqplmdnlesqtyevfekdpikysqyqqaiykclldrvpee
ekdtnvqvlmvlgagrgplvnaslraakqadrriklyaveknpnavvtlenwqfeewgsq
vtvvssdmrewvapekadiivsellgsfadnelspecldgaqhflkddgvsipgeytsfl
apisssklynevracrekdrdpeaqfempyvvrlhnfhqlsapqpcftfshpnrdpmidn
nryctlefpvevntvlhgfagyfetvlyqditlsirpethspgmfswfpilfpikqpitv
regqticvrfwrcsnskkvwyewavtapvcsaihnptgrsytigl

    Sequence, based on observed residues (ATOM records):
    >7kidA (A:)
rvssgrdlncvpeiadtlgavakqgfdflcmpvfhprfkrefiqepaknrpgpqtrsdll
lsgrdwntlivgklspwirpdskvekirrnseaamlqelnfgaylglpafllplnqednt
nlarvltnhihtghhssmfwmrvplvapedlrddiienaptthteeysgeektwmwwhnf
rtlcdyskriavaleigadlpsnhvidrwlgepikaailptsifltnkkgfpvlskmhqr
lifrllklevqfiitgtnhhsekefcsylqyleylsqnrpppnayelfakgyedylqspl
qplmdnlesqtyevfekdpikysqyqqaiykclldrvpeeekdtnvqvlmvlgagrgplv
naslraakqadrriklyaveknpnavvtlenwqfeewgsqvtvvssdmrewvapekadii
vsellgsfadnelspecldgaqhflkddgvsipgeytsflapisssklynevracrekdr
dpeaqfempyvvrlhnfhqlsapqpcftfshpnrdpmidnnryctlefpvevntvlhgfa
gyfetvlyqditlsirpethspgmfswfpilfpikqpitvregqticvrfwrcsnskkvw
yewavtapvcsaihnptgrsytigl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7kidB (B:)
mhhhhhhhhrketppplvppaarewnlppnapacmerqleaaryrsdgalllgasslsgr
cwagslwlfkdpcaapnegfcsagvqteagvadltwvgergilvasdsgavelweldene
tlivskfckyehddivstvsvlssgtqavsgskdicikvwdlaqqvvlssyrahaaqvtc
vaasphkdsvflscsednrillwdtrcpkpasqigcsapgylptslawhpqqsevfvfgd
engtvslvdtkstscvlssavhsqcvtglvfsphsvpflaslsedcslavldsslselfr
sqahrdfvrdatwsplnhsllttvgwdhqvvhhvvpteplpapgpasvte

    Sequence, based on observed residues (ATOM records):
    >7kidB (B:)
nlppnapacmerqleaaryrsdgalllgasslsgrcwagslwlfkdpcaapnegfcsagv
qteagvadltwvgergilvasdsgavelweldenetlivskfckyehddivstvsvlssg
tqavsgskdicikvwdlaqqvvlssyrahaaqvtcvaasphkdsvflscsednrillwdt
rcpkpasqigcsapgylptslawhpqqsevfvfgdengtvslvdtkstscvlssavhsqc
vtglvfsphsvpflaslsedcslavldsslselfrsqahrdfvrdatwsplnhsllttvg
wdhqvvhhvvp