PDB entry 7kde

View 7kde on RCSB PDB site
Description: bg505 sosip.664 in complex with the v3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8anc195
Deposited on 2020-10-08, released 2020-10-28
The last revision was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: EM
Resolution: 3.55 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (93)
  • Chain 'B':
    Compound: HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (93)
  • Chain 'C':
    Compound: HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (93)
  • Chain 'E':
    Compound: envelope glycoprotein gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • conflict (298)
      • conflict (466)
  • Chain 'F':
    Compound: envelope glycoprotein gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • conflict (298)
      • conflict (466)
  • Chain 'G':
    Compound: envelope glycoprotein gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • conflict (298)
      • conflict (466)
  • Chain 'H':
    Compound: Ab 1485 Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'I':
    Compound: Ab 1485 Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE
  • Chain 'J':
    Compound: Ab 1485 Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'L':
    Compound: Ab 1485 Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE
  • Chain 'M':
    Compound: Ab 1485 Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'N':
    Compound: Ab 1485 Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE
  • Chain 'O':
    Compound: 8ANC195 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'P':
    Compound: 8ANC195 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'Q':
    Compound: 8ANC195 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'R':
    Compound: 8ANC195 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'S':
    Compound: 8ANC195 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Chain 'T':
    Compound: 8ANC195 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7KDE (0-End)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7kdeA (A:)
avgigavflgflgaagstmgaasmtltvqarnllsgivqqqsnllrapeaqqhllkltvw
gikqlqarvlaverylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqw
dkeisnytqiiyglleesqnqqekneqdllald

    Sequence, based on observed residues (ATOM records):
    >7kdeA (A:)
flgflgaagstmgaasmtltvqarnllstvwgikqlqarvlaverylrdqqllgiwgcsg
klicctnvpwnsswsnrnlseiwdnmtwlqwdkeisnytqiiyglleesqnqqekneqdl
lal

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7kdeB (B:)
avgigavflgflgaagstmgaasmtltvqarnllsgivqqqsnllrapeaqqhllkltvw
gikqlqarvlaverylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqw
dkeisnytqiiyglleesqnqqekneqdllald

    Sequence, based on observed residues (ATOM records):
    >7kdeB (B:)
flgflgaagstmgaasmtltvqarnllstvwgikqlqarvlaverylrdqqllgiwgcsg
klicctnvpwnsswsnrnlseiwdnmtwlqwdkeisnytqiiyglleesqnqqekneqdl
lal

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7kdeC (C:)
avgigavflgflgaagstmgaasmtltvqarnllsgivqqqsnllrapeaqqhllkltvw
gikqlqarvlaverylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqw
dkeisnytqiiyglleesqnqqekneqdllald

    Sequence, based on observed residues (ATOM records):
    >7kdeC (C:)
flgflgaagstmgaasmtltvqarnllstvwgikqlqarvlaverylrdqqllgiwgcsg
klicctnvpwnsswsnrnlseiwdnmtwlqwdkeisnytqiiyglleesqnqqekneqdl
lal

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7kdeE (E:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcvtlqctnvtnnitddmrgelkncsfn
mttelrdkkqkvyslfyrldvvqinenqgnrsnnsnkeyrlincntsaitqacpkvsfep
ipihycapagfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmi
rsenitnnaknilvqfntpvqinctrpnnntrksirigpgqafyatgdiigdirqahcnv
skatwnetlgkvvkqlrkhfgnntiirfanssggdlevtthsfncggeffycntsglfns
twisntsvqgsnstgsndsitlpcrikqiinmwqrigqamyappiqgvircvsnitglil
trdggstnsttetfrpgggdmrdnwrselykykvvkieplgvaptrckrrvvgrrrrrr

    Sequence, based on observed residues (ATOM records):
    >7kdeE (E:)
lwvtvyygvpvwkdaettlfcasdkhnvwathacvptdqeihlenvteefnmwknnmveq
mhtdiislwdqslkpcvkltplcvtlqctnvtgelkncsfnmttelrdkkqkvyslfyrl
dvvqinnkeyrlincntsaitqacpkvsfepipihycapagfailkckdkkfngtgpcps
vstvqcthgikpvvstqlllngslaeeevmirsenitnnaknilvqfntpvqinctrpnn
ntrksirigpgqafyatgdiigdirqahcnvskatwnetlgkvvkqlrkhfgnntiirfa
nssggdlevtthsfncggeffycntsglfnstwisndsitlpcrikqiinmwqrigqamy
appiqgvircvsnitgliltrdggstnsttetfrpgggdmrdnwrselykykvvkieplg
vaptrckrr

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7kdeF (F:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcvtlqctnvtnnitddmrgelkncsfn
mttelrdkkqkvyslfyrldvvqinenqgnrsnnsnkeyrlincntsaitqacpkvsfep
ipihycapagfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmi
rsenitnnaknilvqfntpvqinctrpnnntrksirigpgqafyatgdiigdirqahcnv
skatwnetlgkvvkqlrkhfgnntiirfanssggdlevtthsfncggeffycntsglfns
twisntsvqgsnstgsndsitlpcrikqiinmwqrigqamyappiqgvircvsnitglil
trdggstnsttetfrpgggdmrdnwrselykykvvkieplgvaptrckrrvvgrrrrrr

    Sequence, based on observed residues (ATOM records):
    >7kdeF (F:)
lwvtvyygvpvwkdaettlfcasdkhnvwathacvptdqeihlenvteefnmwknnmveq
mhtdiislwdqslkpcvkltplcvtlqctnvtgelkncsfnmttelrdkkqkvyslfyrl
dvvqinnkeyrlincntsaitqacpkvsfepipihycapagfailkckdkkfngtgpcps
vstvqcthgikpvvstqlllngslaeeevmirsenitnnaknilvqfntpvqinctrpnn
ntrksirigpgqafyatgdiigdirqahcnvskatwnetlgkvvkqlrkhfgnntiirfa
nssggdlevtthsfncggeffycntsglfnstwisndsitlpcrikqiinmwqrigqamy
appiqgvircvsnitgliltrdggstnsttetfrpgggdmrdnwrselykykvvkieplg
vaptrckrr

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7kdeG (G:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcvtlqctnvtnnitddmrgelkncsfn
mttelrdkkqkvyslfyrldvvqinenqgnrsnnsnkeyrlincntsaitqacpkvsfep
ipihycapagfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmi
rsenitnnaknilvqfntpvqinctrpnnntrksirigpgqafyatgdiigdirqahcnv
skatwnetlgkvvkqlrkhfgnntiirfanssggdlevtthsfncggeffycntsglfns
twisntsvqgsnstgsndsitlpcrikqiinmwqrigqamyappiqgvircvsnitglil
trdggstnsttetfrpgggdmrdnwrselykykvvkieplgvaptrckrrvvgrrrrrr

    Sequence, based on observed residues (ATOM records):
    >7kdeG (G:)
lwvtvyygvpvwkdaettlfcasdkhnvwathacvptdqeihlenvteefnmwknnmveq
mhtdiislwdqslkpcvkltplcvtlqctnvtgelkncsfnmttelrdkkqkvyslfyrl
dvvqinnkeyrlincntsaitqacpkvsfepipihycapagfailkckdkkfngtgpcps
vstvqcthgikpvvstqlllngslaeeevmirsenitnnaknilvqfntpvqinctrpnn
ntrksirigpgqafyatgdiigdirqahcnvskatwnetlgkvvkqlrkhfgnntiirfa
nssggdlevtthsfncggeffycntsglfnstwisndsitlpcrikqiinmwqrigqamy
appiqgvircvsnitgliltrdggstnsttetfrpgggdmrdnwrselykykvvkieplg
vaptrckrr

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7kdeH (H:)
evqlvesgpglvkasetlsltctvsgynirsnnwwswvrqppgkglewiggvyanseitn
ynsslksrvsisqdawrnkfslklksvtdadtavyycvrgpnhweyfdsgnneyfefwgq
galvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdk

    Sequence, based on observed residues (ATOM records):
    >7kdeH (H:)
evqlvesgpglvkasetlsltctvsgynirsnnwwswvrqppgkglewiggvyanseitn
ynsslksrvsisqdawrnkfslklksvtdadtavyycvrgpnhweyfdsgnneyfefwgq
galvtvssa

  • Chain 'I':
    Sequence, based on SEQRES records:
    >7kdeI (I:)
qsaltqppsvsgapgqrvtisctgtssnienyhafwyqqfsgmapkllirdndkrpsgvs
drfsgsksgasasltitglqtddeadyycqsydsglrsyifasgtrltvlgqpkasptvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >7kdeI (I:)
saltqppsvsgapgqrvtisctgenyhafwyqqfsgmapkllirdndkrpsgvsdrfsgs
ksgasasltitglqtddeadyycqsydsglrsyifasgtrltv

  • Chain 'J':
    Sequence, based on SEQRES records:
    >7kdeJ (J:)
evqlvesgpglvkasetlsltctvsgynirsnnwwswvrqppgkglewiggvyanseitn
ynsslksrvsisqdawrnkfslklksvtdadtavyycvrgpnhweyfdsgnneyfefwgq
galvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdk

    Sequence, based on observed residues (ATOM records):
    >7kdeJ (J:)
evqlvesgpglvkasetlsltctvsgynirsnnwwswvrqppgkglewiggvyanseitn
ynsslksrvsisqdawrnkfslklksvtdadtavyycvrgpnhweyfdsgnneyfefwgq
galvtvssa

  • Chain 'L':
    Sequence, based on SEQRES records:
    >7kdeL (L:)
qsaltqppsvsgapgqrvtisctgtssnienyhafwyqqfsgmapkllirdndkrpsgvs
drfsgsksgasasltitglqtddeadyycqsydsglrsyifasgtrltvlgqpkasptvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >7kdeL (L:)
saltqppsvsgapgqrvtisctgenyhafwyqqfsgmapkllirdndkrpsgvsdrfsgs
ksgasasltitglqtddeadyycqsydsglrsyifasgtrltv

  • Chain 'M':
    Sequence, based on SEQRES records:
    >7kdeM (M:)
evqlvesgpglvkasetlsltctvsgynirsnnwwswvrqppgkglewiggvyanseitn
ynsslksrvsisqdawrnkfslklksvtdadtavyycvrgpnhweyfdsgnneyfefwgq
galvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdk

    Sequence, based on observed residues (ATOM records):
    >7kdeM (M:)
evqlvesgpglvkasetlsltctvsgynirsnnwwswvrqppgkglewiggvyanseitn
ynsslksrvsisqdawrnkfslklksvtdadtavyycvrgpnhweyfdsgnneyfefwgq
galvtvssa

  • Chain 'N':
    Sequence, based on SEQRES records:
    >7kdeN (N:)
qsaltqppsvsgapgqrvtisctgtssnienyhafwyqqfsgmapkllirdndkrpsgvs
drfsgsksgasasltitglqtddeadyycqsydsglrsyifasgtrltvlgqpkasptvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >7kdeN (N:)
saltqppsvsgapgqrvtisctgenyhafwyqqfsgmapkllirdndkrpsgvsdrfsgs
ksgasasltitglqtddeadyycqsydsglrsyifasgtrltv

  • Chain 'O':
    Sequence, based on SEQRES records:
    >7kdeO (O:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydrwsglhhdgvmafs
swgqgtlisvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthh
hhhh

    Sequence, based on observed residues (ATOM records):
    >7kdeO (O:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydrwsglhhdgvmafs
swgqgtlisvsa

  • Chain 'P':
    Sequence, based on SEQRES records:
    >7kdeP (P:)
diqmtqspstlsastgdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfrgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7kdeP (P:)
diqmtqspstlsastgdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfrgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvev

  • Chain 'Q':
    Sequence, based on SEQRES records:
    >7kdeQ (Q:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydrwsglhhdgvmafs
swgqgtlisvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthh
hhhh

    Sequence, based on observed residues (ATOM records):
    >7kdeQ (Q:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydrwsglhhdgvmafs
swgqgtlisvsa

  • Chain 'R':
    Sequence, based on SEQRES records:
    >7kdeR (R:)
diqmtqspstlsastgdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfrgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7kdeR (R:)
diqmtqspstlsastgdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfrgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvev

  • Chain 'S':
    Sequence, based on SEQRES records:
    >7kdeS (S:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydrwsglhhdgvmafs
swgqgtlisvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthh
hhhh

    Sequence, based on observed residues (ATOM records):
    >7kdeS (S:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydrwsglhhdgvmafs
swgqgtlisvsa

  • Chain 'T':
    Sequence, based on SEQRES records:
    >7kdeT (T:)
diqmtqspstlsastgdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfrgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7kdeT (T:)
diqmtqspstlsastgdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfrgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvev