PDB entry 7kcw

View 7kcw on RCSB PDB site
Description: Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with nafcillin
Class: hydrolase/hydrolase inhibitor
Keywords: acyl-enzyme intermediate, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2020-10-07, released 2021-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 1.73 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Penicillin-binding protein 4
    Species: Staphylococcus aureus (strain COL) [TaxId:93062]
    Gene: pbp4, SACOL0699
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0H2WY27 (Start-366)
      • engineered mutation (183)
    Domains in SCOPe 2.08: d7kcwa1, d7kcwa2
  • Heterogens: NFF, GOL, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kcwA (A:)
gshmyaqatnsdvtpvqaanqygyaglsaayeptsavnvsqtgqllyqynidtkwnpasm
tklmtmyltleavnkgqlslddtvtmtnkeyimstlpelsntklypgqvwtiadllqitv
snssnaaalilakkvskntsdfvdlmnnkakaigmknthfvnptgaensrlrtfaptkyk
dqeltvttardyaildlhviketpkildftkqlaptthavtyytfnfslegakmslpgtd
glktgssdtanynhtittkrgkfrinqvimgagdyknlggekqrnmmgnalmersfdqyk
yvkilskgeqringkkyyvendlydvlpsdfskkdyklvvedgkvhadyprefinkdygp
ptvevhq

    Sequence, based on observed residues (ATOM records): (download) 
    >7kcwA (A:)
atnsdvtpvqaanqygyaglsaayeptsavnvsqtgqllyqynidtkwnpasmtklmtmy
ltleavnkgqlslddtvtmtnkeyimstlpelsntklypgqvwtiadllqitvsnssnaa
alilakkvskntsdfvdlmnnkakaigmknthfvnptgaensrlrtfaptkykdqeltvt
tardyaildlhviketpkildftkqlaptthavtyytfnfslegakmslpgtdglktgss
dtanynhtittkrgkfrinqvimgagdyknlggekqrnmmgnalmersfdqykyvkilsk
geqringkkyyvendlydvlpsdfskkdyklvvedgkvhadyprefinkdygpptvevhq