PDB entry 7kbh

View 7kbh on RCSB PDB site
Description: structure of human hdac2 in complex with a 2-substituted benzamide inhibitor (compound 16)
Deposited on 2020-10-02, released 2020-12-30
The last revision was dated 2020-12-30, with a file datestamp of 2020-12-25.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92769
      • insertion (204)
  • Chain 'B':
    Compound: Histone deacetylase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92769
      • insertion (204)
  • Chain 'C':
    Compound: Histone deacetylase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92769
      • insertion (204)
  • Heterogens: WB4, ZN, CA, PEG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7kbhA (A:)
maysqgggkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphka
taeemtkyhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsva
gavklnrqqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihh
gdgveeafyttdrvmtvsfhkygeyyfpgtgdlrdigagkgkyyavnfpmrdgiddesyg
qifkpiiskvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllml
ggggytirnvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpey
mekikqrlfenlrmlph

    Sequence, based on observed residues (ATOM records):
    >7kbhA (A:)
gkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtk
yhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnr
qqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveea
fyttdrvmtvsfhkygeyyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpii
skvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggyti
rnvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqr
lfenlrmlp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7kbhB (B:)
maysqgggkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphka
taeemtkyhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsva
gavklnrqqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihh
gdgveeafyttdrvmtvsfhkygeyyfpgtgdlrdigagkgkyyavnfpmrdgiddesyg
qifkpiiskvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllml
ggggytirnvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpey
mekikqrlfenlrmlph

    Sequence, based on observed residues (ATOM records):
    >7kbhB (B:)
kkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtkyh
sdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnrqq
tdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveeafy
ttdrvmtvsfhkygeyyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiisk
vmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytirn
varcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrlf
enlrml

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7kbhC (C:)
maysqgggkkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphka
taeemtkyhsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsva
gavklnrqqtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihh
gdgveeafyttdrvmtvsfhkygeyyfpgtgdlrdigagkgkyyavnfpmrdgiddesyg
qifkpiiskvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllml
ggggytirnvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpey
mekikqrlfenlrmlph

    Sequence, based on observed residues (ATOM records):
    >7kbhC (C:)
kkkvcyyydgdignyyygqghpmkphrirmthnlllnyglyrkmeiyrphkataeemtky
hsdeyikflrsirpdnmseyskqmqrfnvgedcpvfdglfefcqlstggsvagavklnrq
qtdmavnwagglhhakkseasgfcyvndivlailellkyhqrvlyididihhgdgveeaf
yttdrvmtvsfhkygeyyfpgtgdlrdigagkgkyyavnfpmrdgiddesygqifkpiis
kvmemyqpsavvlqcgadslsgdrlgcfnltvkghakcvevvktfnlpllmlggggytir
nvarcwtyetavaldceipnelpyndyfeyfgpdfklhispsnmtnqntpeymekikqrl
fenlrml