PDB entry 7k8g

View 7k8g on RCSB PDB site
Description: Crystal structure of bovine RPE65 in complex with 4-fluoro-MB-004 and palmitate
Class: isomerase,hydrolase/inhibitor
Keywords: non-heme iron, inhibitor, beta propeller, ISOMERASE, isomerohydrolase, HYDROLASE-INHIBITOR complex
Deposited on 2020-09-27, released 2021-06-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (0-531)
      • conflict (339)
    Domains in SCOPe 2.08: d7k8ga_
  • Chain 'B':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (0-531)
      • conflict (339)
    Domains in SCOPe 2.08: d7k8gb_
  • Heterogens: W9A, FE2, PLM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7k8gA (A:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrffs
yfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahp
hiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyvh
sfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyin
nkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarkap
qpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpqi
nyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdalee
ddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >7k8gA (A:)
sqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlfd
gqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafevtdnalvniypvg
edyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynignciayni
vkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlfkgan
ymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedheflivdlccwkgf
efvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknlvtlpnttatai
lcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfvpdrlcklnvkt
ketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayllilnakdlseva
raeveinipvtfhglfkks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7k8gB (B:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrffs
yfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahp
hiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyvh
sfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyin
nkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarkap
qpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpqi
nyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdalee
ddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >7k8gB (B:)
sqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlfd
gqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpgvevtdnalvniy
pvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncia
ynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlfk
ganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedheflivdlccw
kgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknlvtlpntta
tailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfvpdrlckln
vktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayllilnakdls
evaraeveinipvtfhglfkks