PDB entry 7k6q

View 7k6q on RCSB PDB site
Description: active state dot1 bound to the h4k16ac nucleosome
Deposited on 2020-09-21, released 2021-02-10
The last revision was dated 2021-02-10, with a file datestamp of 2021-02-05.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone H3.2
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P84233 (0-97)
      • engineered mutation (42)
      • engineered mutation (65)
  • Chain 'B':
    Compound: histone h4
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Histone H2A type 1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06897 (0-106)
      • engineered mutation (87)
  • Chain 'D':
    Compound: Histone H2B 1.1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02281 (0-92)
      • engineered mutation (0)
      • engineered mutation (88)
  • Chain 'E':
    Compound: Histone H3.2
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P84233 (Start-97)
      • engineered mutation (42)
      • engineered mutation (65)
  • Chain 'F':
    Compound: histone h4
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Histone H2A type 1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06897 (0-106)
      • engineered mutation (87)
  • Chain 'H':
    Compound: Histone H2B 1.1
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02281 (0-92)
      • engineered mutation (0)
      • engineered mutation (88)
  • Chain 'I':
    Compound: DNA (146-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'J':
    Compound: DNA (146-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'K':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG48 (Start-75)
      • engineered mutation (75)
  • Heterogens: ALY, SAM

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >7k6qA (A:)
kphryrpgtvalreirryqkstellirklpfqrlvreiaqdfmtdlrfqssavmalqeas
eaylvalfedtnlcaihakrvtimpkdiqlarrirger

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7k6qB (B:)
gkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdav
tytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >7k6qB (B:)
gkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdav
tytehakrktvtamdvvyalkrqgrtlygfg

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >7k6qC (C:)
akaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagnaar
dnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpk

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >7k6qD (D:)
trkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahynkrstits
reiqtavrlllpgelakhavsegtkavtcytsa

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7k6qE (E:)
kphryrpgtvalreirryqkstellirklpfqrlvreiaqdfmtdlrfqssavmalqeas
eaylvalfedtnlcaihakrvtimpkdiqlarrirger

    Sequence, based on observed residues (ATOM records):
    >7k6qE (E:)
ryrpgtvalreirryqkstellirklpfqrlvreiaqdfmtdlrfqssavmalqeaseay
lvalfedtnlcaihakrvtimpkdiqlarrirger

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7k6qF (F:)
gkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdav
tytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >7k6qF (F:)
krhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtyteh
akrktvtamdvvyalkrqgrtlygfgg

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >7k6qG (G:)
akaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagnaar
dnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpk

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >7k6qH (H:)
trkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahynkrstits
reiqtavrlllpgelakhavsegtkavtcytsa

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records:
    >7k6qK (K:)
sstfvdwngpclrlqyplfdieylrsheiysgtpiqsislrtnspqptsltsdndtssvt
taklqsilfsnymeeykvdfkrstaiynpmseigklieysclvflpspyaeqlketilpd
lnasfdnsdtkgfvnainlynkmireiprqriidhletidkiprsfihdflhivytrsih
pqanklkhykafsnyvygellpnflsdvyqqcqlkkgdtfmdlgsgvgncvvqaalecgc
alsfgceimddasdltilqyeelkkrcklygmrlnnvefslkksfvdnnrvaelipqcdv
ilvnnflfdedlnkkvekilqtakvgckiislkslrsltyqinfynvenifnrlkvqryd
lkedsvswthsggeyyistvmedvdeslfspaargrrnrgtpvkym

    Sequence, based on observed residues (ATOM records):
    >7k6qK (K:)
sstfvdwngpclrlqyplfdieylrsheiysgtpiqsislrttaklqsilfsnymeeykv
dfkrstaiynpmseigklieysclvflpspyaeqlketilpdlnasfdnsdtkgfvnain
lynkmireiprqriidhletidkiprsfihdflhivytrsihpqanklkhykafsnyvyg
ellpnflsdvyqqcqlkkgdtfmdlgsgvgncvvqaalecgcalsfgceimddasdltil
qyeelkkrcklygmrlnnvefslkksfvdnnrvaelipqcdvilvnnflfdedlnkkvek
ilqtakvgckiislkslrsltyqinfynvenifnrlkvqrydlkedsvswthsggeyyis
tvmedvdeslfspaargrrpvky

  • Chain 'L':
    Sequence, based on SEQRES records:
    >7k6qL (L:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgc

    Sequence, based on observed residues (ATOM records):
    >7k6qL (L:)
qifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyni
qkestlhlvlrlrgc