PDB entry 7k4d

View 7k4d on RCSB PDB site
Description: cryo-em structure of human trpv6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3og
Deposited on 2020-09-15, released 2020-12-09
The last revision was dated 2020-12-09, with a file datestamp of 2020-12-04.
Experiment type: EM
Resolution: 3.66 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: VUM, CA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7k4dA (A:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4dA (A:)
swaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalhiaa
lydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvsara
tgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhililqp
nktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrkhtq
wtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkrygrp
yfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddirlv
gelvtvigaiiillvevpdifrmgvtrffgqtilggpfhvliityafmvlvtmvmrlisa
sgevvpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasa
fyiifqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiat
llmlnlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgd
rwflrvedrqdl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7k4dB (B:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4dB (B:)
swaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalhiaa
lydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvsara
tgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhililqp
nktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrkhtq
wtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkrygrp
yfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddirlv
gelvtvigaiiillvevpdifrmgvtrffgqtilggpfhvliityafmvlvtmvmrlisa
sgevvpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasa
fyiifqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiat
llmlnlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgd
rwflrvedrqdl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7k4dC (C:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4dC (C:)
swaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalhiaa
lydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvsara
tgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhililqp
nktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrkhtq
wtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkrygrp
yfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddirlv
gelvtvigaiiillvevpdifrmgvtrffgqtilggpfhvliityafmvlvtmvmrlisa
sgevvpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasa
fyiifqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiat
llmlnlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgd
rwflrvedrqdl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7k4dD (D:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4dD (D:)
swaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalhiaa
lydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvsara
tgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhililqp
nktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrkhtq
wtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkrygrp
yfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddirlv
gelvtvigaiiillvevpdifrmgvtrffgqtilggpfhvliityafmvlvtmvmrlisa
sgevvpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasa
fyiifqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiat
llmlnlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgd
rwflrvedrqdl