PDB entry 7k4b

View 7k4b on RCSB PDB site
Description: cryo-em structure of human trpv6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a
Deposited on 2020-09-15, released 2020-12-09
The last revision was dated 2020-12-09, with a file datestamp of 2020-12-04.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: VUG, Y01, PCW, CA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7k4bA (A:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4bA (A:)
wfqrreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamget
alhiaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarra
svsaratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlh
ililqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmq
krkhtqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkw
krygrpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpk
ddirlvgelvtvigaiiillvevpdifrmgvtpfhvliityafmvlvtmvmrlisasgev
vpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyii
fqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllml
nlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwfl
rvedrqd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7k4bB (B:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4bB (B:)
wfqrreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamget
alhiaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarra
svsaratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlh
ililqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmq
krkhtqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkw
krygrpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpk
ddirlvgelvtvigaiiillvevpdifrmgvtpfhvliityafmvlvtmvmrlisasgev
vpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyii
fqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllml
nlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwfl
rvedrqd

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7k4bC (C:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4bC (C:)
wfqrreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamget
alhiaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarra
svsaratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlh
ililqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmq
krkhtqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkw
krygrpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpk
ddirlvgelvtvigaiiillvevpdifrmgvtpfhvliityafmvlvtmvmrlisasgev
vpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyii
fqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllml
nlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwfl
rvedrqd

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7k4bD (D:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4bD (D:)
wfqrreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamget
alhiaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarra
svsaratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlh
ililqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmq
krkhtqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkw
krygrpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpk
ddirlvgelvtvigaiiillvevpdifrmgvtpfhvliityafmvlvtmvmrlisasgev
vpmsfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyii
fqtedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllml
nlliammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwfl
rvedrqd