PDB entry 7k4a

View 7k4a on RCSB PDB site
Description: cryo-em structure of human trpv6 in the open state
Deposited on 2020-09-15, released 2020-12-09
The last revision was dated 2020-12-09, with a file datestamp of 2020-12-04.
Experiment type: EM
Resolution: 3.26 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Transient receptor potential cation channel subfamily V member 6
    Species: Homo sapiens [TaxId:9606]
    Gene: TRPV6, ECAC2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: Y01, PCW, CA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7k4aA (A:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4aA (A:)
rreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalh
iaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvs
aratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhili
lqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrk
htqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkry
grpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddi
rlvgelvtvigaiiillvevpdifrmgvtrpfhvliityafmvlvtmvmrlisasgevvp
msfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyiifq
tedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllmlnl
liammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwflrv
edrqd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7k4aB (B:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4aB (B:)
rreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalh
iaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvs
aratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhili
lqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrk
htqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkry
grpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddi
rlvgelvtvigaiiillvevpdifrmgvtrpfhvliityafmvlvtmvmrlisasgevvp
msfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyiifq
tedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllmlnl
liammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwflrv
edrqd

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7k4aC (C:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4aC (C:)
rreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalh
iaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvs
aratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhili
lqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrk
htqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkry
grpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddi
rlvgelvtvigaiiillvevpdifrmgvtrpfhvliityafmvlvtmvmrlisasgevvp
msfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyiifq
tedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllmlnl
liammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwflrv
edrqd

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7k4aD (D:)
mglslpkekglilclwskfcrwfqrreswaqsrdeqnllqqkriwesplllaakdndvqa
lnkllkyedckvhqrgamgetalhiaalydnleaamvlmeaapelvfepmtselyegqta
lhiavvnqnmnlvrallarrasvsaratgtafrrspcnliyfgehplsfaacvnseeivr
lliehgadiraqdslgntvlhililqpnktfacqmynlllsydrhgdhlqpldlvpnhqg
ltpfklagvegntvmfqhlmqkrkhtqwtygpltstlydlteidssgdeqslleliittk
krearqildqtpvkelvslkwkrygrpyfcmlgaiyllyiicftmcciyrplkprtnnrt
sprdntllqqkllqeaymtpkddirlvgelvtvigaiiillvevpdifrmgvtrffgqti
lggpfhvliityafmvlvtmvmrlisasgevvpmsfalvlgwcnvmyfargfqmlgpfti
miqkmifgdlmrfcwlmavvilgfasafyiifqtedpeelghfydypmalfstfelflti
idgpanynvdlpfmysityaafaiiatllmlnlliammgdthwrvaherdelwraqivat
tvmlerklprclwprsgicgreyglgdrwflrvedrqdlnrqriqryaqafhtrgsedld
kdsveklvpr

    Sequence, based on observed residues (ATOM records):
    >7k4aD (D:)
rreswaqsrdeqnllqqkriwesplllaakdndvqalnkllkyedckvhqrgamgetalh
iaalydnleaamvlmeaapelvfepmtselyegqtalhiavvnqnmnlvrallarrasvs
aratgtafrrspcnliyfgehplsfaacvnseeivrlliehgadiraqdslgntvlhili
lqpnktfacqmynlllsydrhgdhlqpldlvpnhqgltpfklagvegntvmfqhlmqkrk
htqwtygpltstlydlteidssgdeqslleliittkkrearqildqtpvkelvslkwkry
grpyfcmlgaiyllyiicftmcciyrplkprtnnrtsprdntllqqkllqeaymtpkddi
rlvgelvtvigaiiillvevpdifrmgvtrpfhvliityafmvlvtmvmrlisasgevvp
msfalvlgwcnvmyfargfqmlgpftimiqkmifgdlmrfcwlmavvilgfasafyiifq
tedpeelghfydypmalfstfelfltiidgpanynvdlpfmysityaafaiiatllmlnl
liammgdthwrvaherdelwraqivattvmlerklprclwprsgicgreyglgdrwflrv
edrqd