SCOPe 2.08: Structural Classification of Proteins

PDB entry 7k2x

View 7k2x on RCSB PDB site
Description: Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase
Class: hydrolase
Keywords: antibiotic resistance, CTX-M-14, HYDROLASE
Deposited on 2020-09-09, released 2020-11-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-259)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xa_
Chain 'B':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-259)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xb_
Chain 'C':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-259)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xc_
Chain 'D':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-259)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xd_
Chain 'E':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-End)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xe_
Chain 'F':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-259)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xf_
Chain 'G':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-259)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xg_
Chain 'H':
Compound: Beta-lactamase
Species: Escherichia coli [TaxId:562]
Gene: blaCTX-M
Database cross-references and differences (RAF-indexed):
- Uniprot A0A2H4FY00 (0-259)
  - engineered mutation (138)
  - conflict (211)
Domains in SCOPe 2.08: d7k2xh_
Heterogens: GOL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)

>7k2xA (A:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg

Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)

>7k2xB (B:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg

Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)

>7k2xC (C:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg

Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)

>7k2xD (D:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg

Chain 'E':
Sequence, based on SEQRES records: (download)

>7k2xE (E:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg

Sequence, based on observed residues (ATOM records): (download)

>7k2xE (E:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiae

Chain 'F':
Sequence; same for both SEQRES and ATOM records: (download)

>7k2xF (F:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg

Chain 'G':
Sequence; same for both SEQRES and ATOM records: (download)

>7k2xG (G:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg

Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)

>7k2xH (H:)
savqqklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpqgraplvlvtyftqpq
qnaesrrdvlasaariiaeg