PDB entry 7k2w

View 7k2w on RCSB PDB site
Description: Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase in complex with hydrolyzed cefotaxime
Class: hydrolase
Keywords: antibiotic resistance, acyl-enzyme intermediate, HYDROLASE
Deposited on 2020-09-09, released 2020-11-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.61 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: Escherichia coli [TaxId:562]
    Gene: blaCTX-M
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A2H4FY00 (0-260)
      • conflict (4)
      • engineered mutation (138)
      • conflict (211)
      • conflict (225)
    Domains in SCOPe 2.08: d7k2wa_
  • Heterogens: CEF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7k2wA (A:)
savqnklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpxngraplvlvtyftqp
qqnaesrrdvlasaariiaeg

    Sequence, based on observed residues (ATOM records): (download) 
    >7k2wA (A:)
savqnklaalekssggrlgvalidtadntqvlyrgderfpmcstskvmaaaavlkqsetq
kqllnqpveikpadlvnynpiaekhvngtmtlaelsaaalqysdntamnkliaqlggpgg
vtafaraigdetfrldrtaptlntaipgdprdtttpramaqtlrqltlghalgetqraql
vtwlkgnttgaasiraglptswtvgdrtgsgdygttndiaviwpngraplvlvtyftqpq
qnaesrrdvlasaariiaeg