PDB entry 7k12

View 7k12 on RCSB PDB site
Description: ACMSD in complex with diflunisal
Class: lyase
Keywords: FDA-approved drugs, NAD+, neuropsychiatric disorders, decarboxylase, LYASE
Deposited on 2020-09-07, released 2021-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase
    Species: Pseudomonas fluorescens [TaxId:294]
    Gene: nbaD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7k12a_
  • Chain 'B':
    Compound: 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase
    Species: Pseudomonas fluorescens [TaxId:294]
    Gene: nbaD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7k12b_
  • Heterogens: 1FL, ZN, CIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7k12A (A:)
mghhhhhhhhhhssghiegrhmkkpridmhshffpriseqeaakfdanhapwlqvsakgd
tgsimmgknnfrpvyqalwdpafrieemdaqgvdvqvtcatpvmfgytweankaaqwaer
mndfalefaahnpqrikvlaqvplqdldlackeasravaaghlgiqignhlgdkdlddat
leaflthcanedipilvhpwdmmggqrmkkwmlpwlvampaetqlailslilsgaferip
kslkicfghgggsfafllgrvdnawrhrdivredcprppseyvdrffvdsavfnpgalel
lvsvmgedrvmlgsdypfplgeqkigglvlssnlgesakdkiisgnaskffninv

    Sequence, based on observed residues (ATOM records): (download) 
    >7k12A (A:)
kpridmhshffpriseqeaakfdanhapwlqvsakgdtgsimmgknnfrpvyqalwdpaf
rieemdaqgvdvqvtcatpvmfgytweankaaqwaermndfalefaahnpqrikvlaqvp
lqdldlackeasravaaghlgiqignhlgdkdlddatleaflthcanedipilvhpwdmm
ggqrmkkwmlpwlvampaetqlailslilsgaferipkslkicfghgggsfafllgrvdn
awrhrdivredcprppseyvdrffvdsavfnpgalellvsvmgedrvmlgsdypfplgeq
kigglvlssnlgesakdkiisgnaskffnin

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7k12B (B:)
mghhhhhhhhhhssghiegrhmkkpridmhshffpriseqeaakfdanhapwlqvsakgd
tgsimmgknnfrpvyqalwdpafrieemdaqgvdvqvtcatpvmfgytweankaaqwaer
mndfalefaahnpqrikvlaqvplqdldlackeasravaaghlgiqignhlgdkdlddat
leaflthcanedipilvhpwdmmggqrmkkwmlpwlvampaetqlailslilsgaferip
kslkicfghgggsfafllgrvdnawrhrdivredcprppseyvdrffvdsavfnpgalel
lvsvmgedrvmlgsdypfplgeqkigglvlssnlgesakdkiisgnaskffninv

    Sequence, based on observed residues (ATOM records): (download) 
    >7k12B (B:)
kpridmhshffpriseqeaakfdanhapwlqvsakgdtgsimmgknnfrpvyqalwdpaf
rieemdaqgvdvqvtcatpvmfgytweankaaqwaermndfalefaahnpqrikvlaqvp
lqdldlackeasravaaghlgiqignhlgdkdlddatleaflthcanedipilvhpwdmm
ggqrmkkwmlpwlvampaetqlailslilsgaferipkslkicfghgggsfafllgrvdn
awrhrdivredcprppseyvdrffvdsavfnpgalellvsvmgedrvmlgsdypfplgeq
kigglvlssnlgesakdkiisgnaskffnin