PDB entry 7k0p

View 7k0p on RCSB PDB site
Description: human serine palmitoyltransferase complex sptlc1/spltc2/ssspta/ormdl3, class 4
Deposited on 2020-09-04, released 2021-02-24
The last revision was dated 2021-03-24, with a file datestamp of 2021-03-19.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine palmitoyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTLC1, LCB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Serine palmitoyltransferase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTLC2, KIAA0526, LCB2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Serine palmitoyltransferase small subunit A
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTSSA, C14orf147, SSSPTA
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: ORM1-like protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: ORMDL3
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Serine palmitoyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTLC1, LCB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Serine palmitoyltransferase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTLC2, KIAA0526, LCB2
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Serine palmitoyltransferase small subunit A
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTSSA, C14orf147, SSSPTA
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: ORM1-like protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: ORMDL3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: PLP, POV

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7k0pA (A:)
matateqwvlvemvqalyeapayhlilegililwiirllfsktyklqersdltvkekeel
ieewqpeplvppvpkdhpalnynivsgppshktvvngkecinfasfnflglldnprvkaa
alaslkkygvgtcgprgfygtfdvhldledrlakfmkteeaiiysygfatiasaipaysk
rgdivfvdraacfaiqkglqasrsdiklfkhndmadlerllkeqeiedqknprkarvtrr
fivveglymntgticplpelvklkykykarifleeslsfgvlgehgrgvtehyginiddi
dlisanmenalasiggfccgrsfvidhqrlsgqgycfsaslppllaaaaiealnimeenp
gifavlkekcgqihkalqgisglkvvgeslspafhlqleestgsreqdvrllqeivdqcm
nrsialtqarylekeekclpppsirvvvtveqteeeleraastikevaqavll

    Sequence, based on observed residues (ATOM records):
    >7k0pA (A:)
lvemvqalyeapayhlilegililwiirllfsktyklqersdltvkekeelieewqpepl
vppvpkdhpalnynivsgppshktvvngkecinfasfnflglldnprvkaaalaslkkyg
vgtcgprgfygtfdvhldledrlakfmkteeaiiysygfatiasaipayskrgdivfvdr
aacfaiqkglqasrsdiklfkhndmadlerllkeqeiedqknprkarvtrrfivveglym
ntgticplpelvklkykykarifleeslsfgvlgehgrgvtehyginiddidlisanmen
alasiggfccgrsfvidhqrlsgqgycfsaslppllaaaaiealnimeenpgifavlkek
cgqihkalqgisglkvvgeslspafhlqleestgsreqdvrllqeivdqcmnrsialtqa
rylekeekclpppsirvvvtveqteeeleraastikevaqavll

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7k0pB (B:)
mrpepggcccrrtvrangcvangevrngyvrssaaaaaaaaagqihhvtqngglykrpfn
eafeetpmlvavltyvgygvltlfgylrdflrywriekchhatereeqkdfvslyqdfen
fytrnlymrirdnwnrpicsvpgarvdimerqshdynwsfkytgniikgvinmgsynylg
farntgscqeaaakvleeygagvcstrqeignldkheeleelvarflgveaamaygmgfa
tnsmnipalvgkgclilsdelnhaslvlgarlsgatirifkhnnmqslekllkdaivygq
prtrrpwkkililvegiysmegsivrlpevialkkkykaylyldeahsigalgptgrgvv
eyfgldpedvdvmmgtftksfgasggyiggkkelidylrthshsavyatslsppvveqii
tsmkcimgqdgtslgkecvqqlaentryfrrrlkemgfiiygnedspvvplmlympakig
afgremlkrnigvvvvgfpatpiiesrarfclsaahtkeildtalkeidevgdllqlkys
rhrl

    Sequence, based on observed residues (ATOM records):
    >7k0pB (B:)
glykrpfneafeetpmlvavltyvgygvltlfgylrdflrywriekchhatereeqkdfv
slyqdfenfytrnlymrirdnwnrpicsvpgarvdimerqshdynwsfkytgniikgvin
mgsynylgfarntgscqeaaakvleeygagvcstrqeignldkheeleelvarflgveaa
maygmgfatnsmnipalvgkgclilsdelnhaslvlgarlsgatirifkhnnmqslekll
kdaivygqprtrrpwkkililvegiysmegsivrlpevialkkkykaylyldeahsigal
gptgrgvveyfgldpedvdvmmgtftksfgasggyiggkkelidylrthshsavyatsls
ppvveqiitsmkcimgqdgtslgkecvqqlaentryfrrrlkemgfiiygnedspvvplm
lympakigafgremlkrnigvvvvgfpatpiiesrarfclsaahtkeildtalkeidevg
dllqlkysrhrl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7k0pC (C:)
magmalarawkqmswfyyqyllvtalymlepwertvfnsmlvsivgmalytgyvfmpqhi
mailhyfeivq

    Sequence, based on observed residues (ATOM records):
    >7k0pC (C:)
rawkqmswfyyqyllvtalymlepwertvfnsmlvsivgmalytgyvfmpqhimailhyf
ei

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >7k0pD (D:)
mnvgtahsevnpntrvmnsrgiwlsyvlaigllhivllsipfvsvpvvwtltnlihnmgm
yiflhtvkgtpfetpdqgkarllthweqmdygvqftasrkfltitpivlyfltsfytkyd
qihfvlntvslmsvlipklpqlhgvrifginky

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7k0pE (E:)
matateqwvlvemvqalyeapayhlilegililwiirllfsktyklqersdltvkekeel
ieewqpeplvppvpkdhpalnynivsgppshktvvngkecinfasfnflglldnprvkaa
alaslkkygvgtcgprgfygtfdvhldledrlakfmkteeaiiysygfatiasaipaysk
rgdivfvdraacfaiqkglqasrsdiklfkhndmadlerllkeqeiedqknprkarvtrr
fivveglymntgticplpelvklkykykarifleeslsfgvlgehgrgvtehyginiddi
dlisanmenalasiggfccgrsfvidhqrlsgqgycfsaslppllaaaaiealnimeenp
gifavlkekcgqihkalqgisglkvvgeslspafhlqleestgsreqdvrllqeivdqcm
nrsialtqarylekeekclpppsirvvvtveqteeeleraastikevaqavll

    Sequence, based on observed residues (ATOM records):
    >7k0pE (E:)
lvemvqalyeapayhlilegililwiirllfsktyklqersdltvkekeelieewqpepl
vppvpkdhpalnynivsgppshktvvngkecinfasfnflglldnprvkaaalaslkkyg
vgtcgprgfygtfdvhldledrlakfmkteeaiiysygfatiasaipayskrgdivfvdr
aacfaiqkglqasrsdiklfkhndmadlerllkeqeiedqknprkarvtrrfivveglym
ntgticplpelvklkykykarifleeslsfgvlgehgrgvtehyginiddidlisanmen
alasiggfccgrsfvidhqrlsgqgycfsaslppllaaaaiealnimeenpgifavlkek
cgqihkalqgisglkvvgeslspafhlqleestgsreqdvrllqeivdqcmnrsialtqa
rylekeekclpppsirvvvtveqteeeleraastikevaqavll

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7k0pF (F:)
mrpepggcccrrtvrangcvangevrngyvrssaaaaaaaaagqihhvtqngglykrpfn
eafeetpmlvavltyvgygvltlfgylrdflrywriekchhatereeqkdfvslyqdfen
fytrnlymrirdnwnrpicsvpgarvdimerqshdynwsfkytgniikgvinmgsynylg
farntgscqeaaakvleeygagvcstrqeignldkheeleelvarflgveaamaygmgfa
tnsmnipalvgkgclilsdelnhaslvlgarlsgatirifkhnnmqslekllkdaivygq
prtrrpwkkililvegiysmegsivrlpevialkkkykaylyldeahsigalgptgrgvv
eyfgldpedvdvmmgtftksfgasggyiggkkelidylrthshsavyatslsppvveqii
tsmkcimgqdgtslgkecvqqlaentryfrrrlkemgfiiygnedspvvplmlympakig
afgremlkrnigvvvvgfpatpiiesrarfclsaahtkeildtalkeidevgdllqlkys
rhrl

    Sequence, based on observed residues (ATOM records):
    >7k0pF (F:)
glykrpfneafeetpmlvavltyvgygvltlfgylrdflrywriekchhatereeqkdfv
slyqdfenfytrnlymrirdnwnrpicsvpgarvdimerqshdynwsfkytgniikgvin
mgsynylgfarntgscqeaaakvleeygagvcstrqeignldkheeleelvarflgveaa
maygmgfatnsmnipalvgkgclilsdelnhaslvlgarlsgatirifkhnnmqslekll
kdaivygqprtrrpwkkililvegiysmegsivrlpevialkkkykaylyldeahsigal
gptgrgvveyfgldpedvdvmmgtftksfgasggyiggkkelidylrthshsavyatsls
ppvveqiitsmkcimgqdgtslgkecvqqlaentryfrrrlkemgfiiygnedspvvplm
lympakigafgremlkrnigvvvvgfpatpiiesrarfclsaahtkeildtalkeidevg
dllqlkysrhrl

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7k0pG (G:)
magmalarawkqmswfyyqyllvtalymlepwertvfnsmlvsivgmalytgyvfmpqhi
mailhyfeivq

    Sequence, based on observed residues (ATOM records):
    >7k0pG (G:)
rawkqmswfyyqyllvtalymlepwertvfnsmlvsivgmalytgyvfmpqhimailhyf
ei

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >7k0pH (H:)
mnvgtahsevnpntrvmnsrgiwlsyvlaigllhivllsipfvsvpvvwtltnlihnmgm
yiflhtvkgtpfetpdqgkarllthweqmdygvqftasrkfltitpivlyfltsfytkyd
qihfvlntvslmsvlipklpqlhgvrifginky