PDB entry 7jyo

View 7jyo on RCSB PDB site
Description: JAK2 JH2 in complex with JAK064
Class: transferase/inhibitor
Keywords: pseudokinase domain, inhibitor, complex, transferase, transferase-inhibitor complex
Deposited on 2020-08-31, released 2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 2.16 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (0-276)
      • engineered mutation (123)
      • engineered mutation (241)
      • engineered mutation (258)
      • expression tag (277-288)
    Domains in SCOPe 2.08: d7jyoa_
  • Heterogens: VPS, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7jyoA (A:)
vfhkirnedlifneslgqgtftkifkgvrrevgdygqlhetevllkvldkahrnysesff
eaasmmsklshkhlvlnygvcvcgdenilvqefvkfgsldtylkknkncinilwklevak
qlaaamhfleentlihgnvcaknillireedrktgnppfiklsdpgisitvlpkdilqer
ipwvppecienpknlnlatdkwsfgttlweicsggdkplsaldsqrklqfyedrhqlpap
kaaelanlinncmdyepdhrpsfraiirdlnslftpdlvprgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7jyoA (A:)
kirnedlifneslgqgtftkifkgvrrevgdygqlhetevllkvldkahrnysesffeaa
smmsklshkhlvlnygvcvcgdenilvqefvkfgsldtylkknkncinilwklevakqla
aamhfleentlihgnvcaknillireedrktgnppfiklsdpgisitvlpkdilqeripw
vppecienpknlnlatdkwsfgttlweicsggdkplsaldsqrklqfyedrhqlpapkaa
elanlinncmdyepdhrpsfraiirdlnsl