PDB entry 7jvr

View 7jvr on RCSB PDB site
Description: cryo-em structure of bromocriptine-bound dopamine receptor 2 in complex with gi protein
Deposited on 2020-08-22, released 2021-02-24
The last revision was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: EM
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63096 (Start-353)
      • engineered mutation (46)
      • engineered mutation (202)
      • engineered mutation (244)
      • engineered mutation (325)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62873 (6-344)
      • expression tag (345-347)
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Antibody fragment ScFv16
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JVR (0-End)
  • Chain 'R':
    Compound: Soluble cytochrome b562,D(2) dopamine receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: DRD2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 08Y

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7jvrA (A:)
mgctlsaedkaaverskmidrnlredgekaarevkllllgagesgkntivkqmkiiheag
yseeeckqykavvysntiqsiiaiiramgrlkidfgdsaraddarqlfvlagaaeegfmt
aelagvikrlwkdsgvqacfnrsreyqlndsaayylndldriaqpnyiptqqdvlrtrvk
ttgivethftfkdlhfkmfdvgaqrserkkwihcfegvtaiifcvalsdydlvlaedeem
nrmhasmklfdsicnnkwftdtsiilflnkkdlfeekikksplticypeyagsntyeeaa
ayiqcqfedlnkrkdtkeiythftcstdtknvqfvfdavtdviiknnlkdcglf

    Sequence, based on observed residues (ATOM records):
    >7jvrA (A:)
lsaedkaaverskmidrnlredgekaarevkllllgagesgkntivkqmkitgivethft
fkdlhfkmfdvgaqrserkkwihcfegvtaiifcvalsdydlvlaedeemnrmhasmklf
dsicnnkwftdtsiilflnkkdlfeekikksplticypeyagsntyeeaaayiqcqfedl
nkrkdtkeiythftcstdtknvqfvfdavtdviiknnlkdcglf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7jvrB (B:)
mgsllqseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghl
akiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacg
gldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgq
qtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicff
pngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncn
vwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwngss

    Sequence, based on observed residues (ATOM records):
    >7jvrB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwngss

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7jvrC (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >7jvrC (C:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7jvrE (E:)
dvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyy
adtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvs
sggggsggggsggggsdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqr
pgqspqlliyrmsnlasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfg
agtklelkgslevlfqgpaaahhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7jvrE (E:)
dvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyy
adtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvs
ssdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqrpgqspqlliyrmsn
lasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfgagtklel

  • Chain 'R':
    Sequence, based on SEQRES records:
    >7jvrR (R:)
dykddddaklqtmhhhhhhhhhhhhhhhadlednwetlndnlkviekadnaaqvkdaltk
mraaaldaqkatppkledkspdspemkdfrhgfdilvgqiddalklanegkvkeaqaaae
qlkttrnayiqkylasenlyfqggtmdplnlswydddlerqnwsrpfngsdgkadrphyn
yyatlltlliavivfgnvlvcmavsrekalqtttnylivslavadllvatlvmpwvvyle
vvgewkfsrihcdifvtldvmmctasilnlcaisidrytavampmlyntrysskrrvtvm
isivwvlsftiscpllfglnnadqneciianpafvvyssivsfyvpfivtllvyikiyiv
lrrrrkrvntkrssrafrahlraplkgncthpedmklctvimksngsfpvnrrrveaarr
aqelememlsstsppertryspippshhqltlpdpshhglhstpdspakpeknghakdhp
kiakifeiqtmpngktrtslktmsrrklsqqkekkatqmlaivlgvfiicwlpffithil
nihcdcnippvlysaftwlgyvnsavnpiiyttfniefrkaflkilhc

    Sequence, based on observed residues (ATOM records):
    >7jvrR (R:)
ynyyatlltlliavivfgnvlvcmavsrekalqtttnylivslavadllvatlvmpwvvy
levvgewkfsrihcdifvtldvmmctasilnlcaisidrytavampmlyntrysskrrvt
vmisivwvlsftiscpllfglnnadqneciianpafvvyssivsfyvpfivtllvyikiy
ivlrrrrkrvntqqkekkatqmlaivlgvfiicwlpffithilnihcdcnippvlysaft
wlgyvnsavnpiiyttfniefrkaflkil