PDB entry 7jvn

View 7jvn on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24
Class: hydrolase/hydrolase inhibitor
Keywords: PHOSPHATASE PTP, INHIBITOR, PTPN11, ALLOSTERIC, SHP2, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2020-08-21, released 2020-09-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-09-23, with a file datestamp of 2020-09-18.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7jvna1, d7jvna2, d7jvna3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7jvnb1, d7jvnb2, d7jvnb3
  • Heterogens: VKP, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >7jvnA (A:)
    mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
    dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
    eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
    vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
    dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
    vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
    ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
    rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
    ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >7jvnA (A:)
    rrwfhpnitgveaenllltrgvdgsflarpsnpgdftlsvrrngavthikiqntgdyydl
    yggekfatlaelvqyymehgqlkielkyplncadptserwfhghlsgkeaeklltekgkh
    gsflvrepgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlvehykknpmvet
    lgtvlqlkqplnttrinaaeiesrvrelsklqgfweefetlqqqeckllysrkegqrqen
    knknryknilpfdhtrvvlhdgdpsdyinaniimpksyiatqgclqntvndfwrmvfqen
    srvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqg
    ntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtf
    ividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >7jvnB (B:)
    mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
    dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
    eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
    vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
    dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
    vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
    ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
    rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
    ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >7jvnB (B:)
    rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
    dlyggekfatlaelvqyymeqlkielkyplncadptserwfhghlsgkeaeklltekgkh
    gsflvrepgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykknpmvetlg
    tvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenknk
    nryknilpfdhtrvvlhvsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivm
    ttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertv
    wqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividil
    idiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl