PDB entry 7jv8

View 7jv8 on RCSB PDB site
Description: human cd73 (ecto 5'-nucleotidase) in complex with compound 35
Deposited on 2020-08-20, released 2020-09-23
The last revision was dated 2020-10-07, with a file datestamp of 2020-10-02.
Experiment type: XRAY
Resolution: 2.46 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-nucleotidase
    Species: Homo sapiens [TaxId:9606]
    Gene: NT5E, NT5, NTE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21589 (4-526)
      • expression tag (2-3)
      • engineered mutation (30)
      • engineered mutation (310)
      • engineered mutation (380)
  • Chain 'B':
    Compound: 5'-nucleotidase
    Species: Homo sapiens [TaxId:9606]
    Gene: NT5E, NT5, NTE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21589 (4-526)
      • expression tag (2-3)
      • engineered mutation (30)
      • engineered mutation (310)
      • engineered mutation (380)
  • Chain 'C':
    Compound: 5'-nucleotidase
    Species: Homo sapiens [TaxId:9606]
    Gene: NT5E, NT5, NTE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21589 (4-526)
      • expression tag (0-3)
      • engineered mutation (30)
      • engineered mutation (310)
      • engineered mutation (380)
      • expression tag (527-528)
  • Chain 'D':
    Compound: 5'-nucleotidase
    Species: Homo sapiens [TaxId:9606]
    Gene: NT5E, NT5, NTE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21589 (4-526)
      • expression tag (2-3)
      • engineered mutation (30)
      • engineered mutation (310)
      • engineered mutation (380)
  • Heterogens: VPD, ZN, CA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7jv8A (A:)
lasmweltilhtndvhsrleqtsedsskcvdasrcmggvarlftkvqqirraepnvllld
agdqyqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsa
nikakgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqp
evdklktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagk
ypfivtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsika
dinkwriklddystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwn
hvsmcilngggirspiderndgtitwenlaavlpfggtfdlvqlkgstlkkafehsvhry
gqstgeflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnfla
nggdgfqmikdellrhdsgdqdinvvstyiskmkviypavegrikfshh

    Sequence, based on observed residues (ATOM records):
    >7jv8A (A:)
smweltilhtndvhsrleqtsedsskcvdasrcmggvarlftkvqqirraepnvllldag
dqyqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsani
kakgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqpev
dklktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagkyp
fivtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsikadi
nkwriklddystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwnhv
smcilngggirspiderndgtitwenlaavlpfggtfdlvqlkgstlkkafehsvhrygq
stgeflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnflang
gdgfqmikdellrhdsgdqdinvvstyiskmkviypavegrikfs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7jv8B (B:)
lasmweltilhtndvhsrleqtsedsskcvdasrcmggvarlftkvqqirraepnvllld
agdqyqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsa
nikakgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqp
evdklktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagk
ypfivtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsika
dinkwriklddystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwn
hvsmcilngggirspiderndgtitwenlaavlpfggtfdlvqlkgstlkkafehsvhry
gqstgeflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnfla
nggdgfqmikdellrhdsgdqdinvvstyiskmkviypavegrikfshh

    Sequence, based on observed residues (ATOM records):
    >7jv8B (B:)
smweltilhtndvhsrleqtsedsskcvdasrcmggvarlftkvqqirraepnvllldag
dqyqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsani
kakasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqpevdkl
ktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagkypfiv
tsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsikadinkw
riklddystqelgktivyldgssqscrfrecnmgnlicdaminnnlemfwnhvsmcilng
ggirspiderndgtitwenlaavlpfggtfdlvqlkgstlkkafehsvhrygqstgeflq
vggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnflanggdgfqmi
kdellrhdsgdqdinvvstyiskmkviypavegrikfs

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >7jv8C (C:)
lasmweltilhtndvhsrleqtsedsskcvdasrcmggvarlftkvqqirraepnvllld
agdqyqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsa
nikakgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqp
evdklktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagk
ypfivtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsika
dinkwriklddystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwn
hvsmcilngggirspiderndgtitwenlaavlpfggtfdlvqlkgstlkkafehsvhry
gqstgeflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnfla
nggdgfqmikdellrhdsgdqdinvvstyiskmkviypavegrikfshh

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7jv8D (D:)
lasmweltilhtndvhsrleqtsedsskcvdasrcmggvarlftkvqqirraepnvllld
agdqyqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsa
nikakgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqp
evdklktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagk
ypfivtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsika
dinkwriklddystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwn
hvsmcilngggirspiderndgtitwenlaavlpfggtfdlvqlkgstlkkafehsvhry
gqstgeflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnfla
nggdgfqmikdellrhdsgdqdinvvstyiskmkviypavegrikfshh

    Sequence, based on observed residues (ATOM records):
    >7jv8D (D:)
smweltilhtndvhsrleqtsedsskcvdasrcmggvarlftkvqqirraepnvllldag
dqyqgtiwftvykgaevahfmnalrydamalgnhefdngvegliepllkeakfpilsani
kakgplasqisglylpykvlpvgdevvgivgytsketpflsnpgtnlvfedeitalqpev
dklktlnvnkiialghsgfemdkliaqkvrgvdvvvgghsntflytgnppskevpagkyp
fivtsddgrkvpvvqayafgkylgylkiefdergnvisshgnpillnssipedpsikadi
nkwriklddystqelgktivyldgssqscrfrecnmgnlicdaminnnlrhtdemfwnhv
smcilngggirspiderndgtitwenlaavlpfggtfdlvqlkgstlkkafehsvhrygq
stgeflqvggihvvydlsrkpgdrvvkldvlctkcrvpsydplkmdevykvilpnflang
gdgfqmikdellrhdsgdqdinvvstyiskmkviypavegrikfs