PDB entry 7juy

View 7juy on RCSB PDB site
Description: Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib
Class: transferase/transferase inhibitor
Keywords: Kinase, Pseudokinase, drug target, cell signaling and cancer, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2020-08-20, released 2020-10-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-30, with a file datestamp of 2020-12-25.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Kinase suppressor of Ras 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Ksr1, Ksr
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7juyb_
  • Chain 'C':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7juyc_
  • Heterogens: ANP, EUI, MG, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7juyB (B:)
msyyhhhhhhdydipttenlyfqgapisrkasqtsvylqewdipfeqvelgepigqgrwg
rvhrgrwhgevairllemdghnqdhlklfkkevmnyrqtrhenvvlfmgacmnpphlaii
tsfckgrtlhsfvrdpktsldinktrqiaqeiikgmgylhakgivhkdlksknvfydngk
vvitdfglfgisgvvregrrenqlklshdwlcylapeivremtpgkdedqlpfskaadvy
afgtvwyelqardwplknqaaeasiwqigsgegmkrvltsvslgkevseilsacwafdlq
erpsfsllmdmleklpklnrrlshpghfwksaei

    Sequence, based on observed residues (ATOM records): (download) 
    >7juyB (B:)
vylqewdipfeqvelgepigqgrwgrvhrgrwhgevairllemdghnqdhlklfkkevmn
yrqtrhenvvlfmgacmnpphlaiitsfckgrtlhsfvrdpktsldinktrqiaqeiikg
mgylhakgivhkdlksknvfydngkvvitdfglfgisgvvenqlklshdwlcylapeivr
emtpgkdedqlpfskaadvyafgtvwyelqardwplknqaaeasiwqigsgegmkrvlts
vslgkevseilsacwafdlqerpsfsllmdmleklp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7juyC (C:)
msyyhhhhhhdydipttenlyfqgakkleeleldeqqrkrleafltqkqkvgelkdddfe
kiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhecnspyivgf
ygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltylrekhkimhr
dvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthysvqsdiwsm
glslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssygmdsrppma
ifelldyivnepppklpsavfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeev
dfagwlcstiglnqpstpthaagv

    Sequence, based on observed residues (ATOM records): (download) 
    >7juyC (C:)
leldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkli
hleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkag
ripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsm
ansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmpmaif
elldyivnepppklpsavfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdf
agwlcstigln