PDB entry 7ju6

View 7ju6 on RCSB PDB site
Description: Structure of RET protein tyrosine kinase in complex with selpercatinib
Class: transferase/transferase inhibitor
Keywords: Transferase, oncogene, RET, Tyrisine Kinase, ATP binding, Thyroid cancer, Non small cell lung cancer, LOXO-292, selpercatinib, Transferase-Transferase inhibitor complex
Deposited on 2020-08-19, released 2020-11-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7ju6a_
  • Chain 'B':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (5-End)
      • expression tag (0-4)
    Domains in SCOPe 2.08: d7ju6b1, d7ju6b2
  • Heterogens: Q6G, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ju6A (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >7ju6A (A:)
edpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlkenaspselrdl
lsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrkvgpgylgpder
altmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeeds
yvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnll
ktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7ju6B (B:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >7ju6B (B:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgsldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisd
fglsrdvsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlf
nllktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkr