PDB entry 7jtt
View 7jtt on RCSB PDB site
Description: The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A in complex F9 inhibitor at the alpha-site and cesium ion at the metal coordination site. The single beta-Q114 rotamer conformation allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring
Class: lyase/lyase inhibitor
Keywords: LYASE, inhibitor complex, tryptophan synthase, LYASE-LYASE INHIBITOR complex
Deposited on
2020-08-18, released
2021-08-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-08-25, with a file datestamp of
2021-08-20.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: N/A
AEROSPACI score: 0.51
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: tryptophan synthase alpha chain
Species: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [TaxId:99287]
Gene: TRPA, STM1727
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d7jtta_ - Chain 'B':
Compound: tryptophan synthase beta chain
Species: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [TaxId:99287]
Gene: trpB, STM1726
Database cross-references and differences (RAF-indexed):
- Uniprot P0A2K1 (0-396)
- engineered mutation (376)
Domains in SCOPe 2.08: d7jttb_ - Heterogens: KOU, F9F, CS, DMS, CL, PEG, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>7jttA (A:)
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
gvtgaenrgalplhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivki
ieknlaspkqmlaelrsfvsamkaasra
- Chain 'B':
Sequence, based on SEQRES records: (download)
>7jttB (B:)
mttllnpyfgefggmyvpqilmpalnqleeafvsaqkdpefqaqfadllknyagrptalt
kcqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasa
lasallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgs
yetahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigm
fadfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysi
sagldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalk
mmreqpekeqllvvnlagrgdkdiftvhdilkargei
Sequence, based on observed residues (ATOM records): (download)
>7jttB (B:)
ttllnpyfgefggmyvpqilmpalnqleeafvsaqkdpefqaqfadllknyagrptaltk
cqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasal
asallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgsy
etahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigmf
adfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysis
agldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalkm
mreqpekeqllvvnlagrgdkdiftvhdilkargei