PDB entry 7jto

View 7jto on RCSB PDB site
Description: Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Class: protein binding
Keywords: Protac, protein degradation, ubiquitination, PROTEIN BINDING
Deposited on 2020-08-18, released 2021-10-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-10-13, with a file datestamp of 2021-10-08.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61964 (4-307)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d7jtob_
  • Chain 'J':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7jtoj_
  • Chain 'K':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7jtok_
  • Chain 'L':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P40337 (2-161)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7jtol_
  • Heterogens: VKA, SCN, EDO, GOL, NA, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7jtoB (B:)
efhmvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisgh
klgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivs
gsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqcl
ktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanf
svtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendkt
iklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >7jtoB (B:)
kpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgis
dvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfde
svriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktlid
ddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtgg
kwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwk
sdc

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >7jtoJ (J:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

    Sequence, based on observed residues (ATOM records): (download) 
    >7jtoJ (J:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvm

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >7jtoK (K:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records): (download) 
    >7jtoK (K:)
myvklissdghefivkrehaltsgtikamlstnevnfreipshvlskvcmyftykvrytn
ssteipefpiapeialellmaanfldc

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7jtoL (L:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >7jtoL (L:)
rprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlw
lfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrr
ldivrslyedledhpnvqkdlerltqer