PDB entry 7joz

View 7joz on RCSB PDB site
Description: crystal structure of dopamine d1 receptor in complex with g protein and a non-catechol agonist
Deposited on 2020-08-07, released 2021-04-14
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62873 (11-349)
      • expression tag (0-10)
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: nanobody 35
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JOZ (0-159)
  • Chain 'R':
    Compound: Endolysin,D(1A) dopamine receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: DRD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot D9IEF7 (46-205)
      • expression tag (0-45)
      • conflict (98)
      • conflict (141)
      • linker (206)
    • Uniprot P21728 (207-533)
      • expression tag (534-539)
  • Heterogens: VFP, 1PE

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7jozA (A:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqm
rilhvngfngdsekatkvqdiknnlkeaietivaamsnlvppvelanpenqfrvdyilsv
mnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfldkidvikqadyvpsd
qdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcfndvtaiifvvasssyn
mvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdllaekvlagkskiedyfpe
faryttpedatpepgedprvtrakyfirdeflristasgdgrhycyphftcavdtenirr
vfndcrdiiqrmhlrqyell

    Sequence, based on observed residues (ATOM records):
    >7jozA (A:)
edqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqmrifngdsek
atkvqdiknnlkeaietivaampenqfrvdyilsvmnvpdfdfppefyehakalwedegv
idcaqyfldkidvikqyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrk
wiqcfndvtaiifvvasssynmednqtnrlqealnlfksiwnnrwlrtisvilflnkqdl
laekvlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgr
hycyphftcavdtenirrvfndcrdiiqrmhlrqyell

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7jozB (B:)
mhhhhhhgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrt
lrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgn
yvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwd
ietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdin
aicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyd
dfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >7jozB (B:)
gseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7jozG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >7jozG (G:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'N':
    Sequence, based on SEQRES records:
    >7jozN (N:)
mkyllptaaagllllaaqpamaqvqlqesggglvqpggslrlscaasgftfsnykmnwvr
qapgkglewvsdisqsgasisytgsvkgrftisrdnakntlylqmnslkpedtavyycar
cpapftrdcfdvtsttyayrgqgtqvtvsshhhhhhepea

    Sequence, based on observed residues (ATOM records):
    >7jozN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvss

  • Chain 'R':
    Sequence, based on SEQRES records:
    >7jozR (R:)
dykddddaaagqpgngsafllapnrshapggggslevlfqgpgggsnifemlrideglrl
kiykdtegyytigighlltkspslnaakseldkaigrntngvitkdeaeklfnqdvdaav
rgilrnaklkpvydsldavrraalinmvfqmgetgvagftnslrmlqqkrwdeaavnlak
srwynqtpnrakrvittfrtgtwdayasvriltacflsllilstllgntlvcaavirfrh
lrskvtnffvislavsdllvavlvmpwkavaeiagfwpfgsfcniwvafdimcstasiln
lcvisvdrywaisspfryerkmtpkaafilisvawtlsvlisfipvqlswhkakptspsd
gnatslaetidncdsslsrtyaisssvisfyipvaimivtytriyriaqkqirriaaler
aavhakncqtttgngkpvecsqpessfkmsfkretkvlktlsvimgvfvccwlpffilnc
ilpfcgsgetqpfcidsntfdvfvwfgwansslnpiiyafnadfrkafstllgchhhhhh

    Sequence, based on observed residues (ATOM records):
    >7jozR (R:)
ifemlrideglrlkiykdtegyytigighlltkspslnaakseldkaigrntngvitkde
aeklfnqdvdaavrgilrnaklkpvydsldavrraalinmvfqmgetgvagftnslrmlq
qkrwdeaavnlaksrwynqtpnrakrvittfrtgtwdayasvriltacflsllilstllg
ntlvcaavirfrhlrskvtnffvislavsdllvavlvmpwkavaeiagfwpfgsfcniwv
afdimcstasilnlcvisvdrywaisspfryerkmtpkaafilisvawtlsvlisfipvq
lswhncdsslsrtyaisssvisfyipvaimivtytriyriaqkqirriaaleraavhakn
cmsfkretkvlktlsvimgvfvccwlpffilncilpfcgsgetqpfcidsntfdvfvwfg
wansslnpiiyafnadfrkafstllg