PDB entry 7jo9

View 7jo9 on RCSB PDB site
Description: 1:1 cgas-nucleosome complex
Deposited on 2020-08-06, released 2020-09-16
The last revision was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: EM
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone H3.2
    Species: Homo sapiens [TaxId:9606]
    Gene: H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: histone h4
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Histone H2A type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Histone H2B type 1-C/E/F/G/I
    Species: Homo sapiens [TaxId:9606]
    Gene: H2BC4, H2BFL, HIST1H2BC, H2BC6, H2BFH, HIST1H2BE, H2BC7, H2BFG, HIST1H2BF, H2BC8, H2BFA, HIST1H2BG, H2BC10, H2BFK, HIST1H2BI
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Histone H3.2
    Species: Homo sapiens [TaxId:9606]
    Gene: H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: histone h4
    Species: Homo sapiens [TaxId:9606]
    Gene: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Histone H2A type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Histone H2B type 1-C/E/F/G/I
    Species: Homo sapiens [TaxId:9606]
    Gene: H2BC4, H2BFL, HIST1H2BC, H2BC6, H2BFH, HIST1H2BE, H2BC7, H2BFG, HIST1H2BF, H2BC8, H2BFA, HIST1H2BG, H2BC10, H2BFK, HIST1H2BI
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: DNA (145-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'J':
    Compound: DNA (145-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'K':
    Compound: Cyclic GMP-AMP synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Cgas, Mb21d1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7jo9A (A:)
martkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkste
llirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvglfedtnlcaihakrvti
mpkdiqlarrirgera

    Sequence, based on observed residues (ATOM records):
    >7jo9A (A:)
kphryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeas
eaylvglfedtnlcaihakrvtimpkdiqlarrirger

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7jo9B (B:)
msgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlk
vflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >7jo9B (B:)
vlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrkt
vtamdvvyalkrqgrtlygfg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7jo9C (C:)
sgrgkqggkarakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavllpkkt
eshhkakgk

    Sequence, based on observed residues (ATOM records):
    >7jo9C (C:)
arakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagna
ardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavllpk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7jo9D (D:)
pepaksapapkkgskkavtkaqkkdgkkrkrsrkesysvyvykvlkqvhpdtgisskamg
imnsfvndiferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtk
ytssk

    Sequence, based on observed residues (ATOM records):
    >7jo9D (D:)
rsrkesysvyvykvlkqvhpdtgisskamgimnsfvndiferiageasrlahynkrstit
sreiqtavrlllpgelakhavsegtkavtkytss

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7jo9E (E:)
martkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkste
llirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvglfedtnlcaihakrvti
mpkdiqlarrirgera

    Sequence, based on observed residues (ATOM records):
    >7jo9E (E:)
phryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqease
aylvglfedtnlcaihakrvtimpkdiqlarrirger

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7jo9F (F:)
msgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlk
vflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >7jo9F (F:)
hrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehak
rktvtamdvvyalkrqgrtlygfgg

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7jo9G (G:)
sgrgkqggkarakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavllpkkt
eshhkakgk

    Sequence, based on observed residues (ATOM records):
    >7jo9G (G:)
arakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagna
ardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavllpk

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7jo9H (H:)
pepaksapapkkgskkavtkaqkkdgkkrkrsrkesysvyvykvlkqvhpdtgisskamg
imnsfvndiferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtk
ytssk

    Sequence, based on observed residues (ATOM records):
    >7jo9H (H:)
rsrkesysvyvykvlkqvhpdtgisskamgimnsfvndiferiageasrlahynkrstit
sreiqtavrlllpgelakhavsegtkavtkytss

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records:
    >7jo9K (K:)
gsrkepdklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveqlntgsyy
ehvkisapnefdvmfklevprielqeyyetgafylvkfkriprgnplshflegevlsatk
mlskfrkiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilaleskgswpis
tkeglpiqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyilnnhgie
ktccessgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdpqdsqwd
prnlsscfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkieyernngf
pifdkl

    Sequence, based on observed residues (ATOM records):
    >7jo9K (K:)
dklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveqlntgsyyehvkis
apnefdvmfklevprielqeyyetgafylvkfkriprgnplshflegevlsatkmlskfr
kiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilaleskgswpistkeglp
iqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyilnnhgiektcces
sgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdpqdsqwdprnlss
cfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkieyernngfpifd