PDB entry 7jic

View 7jic on RCSB PDB site
Description: structure of human cd19-cd81 co-receptor complex bound to coltuximab fab fragment
Deposited on 2020-07-23, released 2021-01-20
The last revision was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: B-lymphocyte antigen CD19
    Species: Homo sapiens [TaxId:9606]
    Gene: CD19
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: CD81 antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: CD81, TAPA1, TSPAN28
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60033
      • conflict (181-182)
  • Chain 'H':
    Compound: Coltuximab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JIC (0-End)
  • Chain 'L':
    Compound: Coltuximab Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JIC (0-End)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7jicA (A:)
dykddddlevlfqgppeeplvvkveegdnavlqclkgtsdgptqqltwsresplkpflkl
slglpglgihmrplaiwlfifnvsqqmggfylcqpgppsekawqpgwtvnvegsgelfrw
nvsdlgglgcglknrssegpsspsgklmspklyvwakdrpeiwegeppclpprdslnqsl
sqdltmapgstlwlscgvppdsvsrgplswthvhpkgpksllslelkddrpardmwvmet
glllprataqdagkyychrgnltmsfhleitarpvlwhwllrtggwkvsavtlaylifcl
cslvgilhlqralvlrrkrkrmt

    Sequence, based on observed residues (ATOM records):
    >7jicA (A:)
eeplvvkveegdnavlqclqqltwsresplkpflklslglpglgihmrplaiwlfifnvs
qqmggfylcqpgppsekawqpgwtvnvegsgelfrwnvsdspklyvwakdrpeiwsqdlt
mapgstlwlscgvppdsvsrgplswthvhpkgpksllslelkddrpardmwvmetglllp
rataqdagkyychrgnltmsfhleittlaylifclcslvgilhlqral

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7jicB (B:)
ggsggsggsggsgvegctkcikyllfvfnfvfwlaggvilgvalwlrhdpqttnllylel
gdkpapntfyvgiyiliavgavmmfvgflgcygaiqesqcllgtfftclvilfacevaag
iwgfvnkdqiakdvkqfydqalqqavvdddannakavvktfhetldccgsstltalttsv
ltsnlcpsgsniisnlfkedchqkiddlfsgklyligiaaivvavimifemilsmvlccg
irnssvy

    Sequence, based on observed residues (ATOM records):
    >7jicB (B:)
cikyllfvfnfvfwlaggvilgvalwlrhdpqttnllylelgdkpapntfyvgiyiliav
gavmmfvgflgcygacllgtfftclvilfacevaagiwgfvndqiakdvkqfydqalqqa
vvnnakavvktfhetldccgsstltalttsnlcpsgsniisnlfkedchqkiddlfsgkl
yligiaaivvavimifemilsmvl

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7jicH (H:)
qvqlvqpgaevvkpgasvklscktsgytftsnwmhwvkqapgqglewigeidpsdsytny
nqnfqgkakltvdkststaymevsslrsddtavyycargsnpyyyamdywgqgtsvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscggsglevlfq

    Sequence, based on observed residues (ATOM records):
    >7jicH (H:)
qvqlvqpgaevvkpgasvklscktsgytftsnwmhwvkqapgqglewigeidpsdsytny
nqnfqgkakltvdkststaymevsslrsddtavyycargsnpyyyamdywgqgtsvtvss
astkgpsvfplapsskgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'L':
    Sequence, based on SEQRES records:
    >7jicL (L:)
eivltqspaimsaspgervtmtcsassgvnymhwyqqkpgtsprrwiydtsklasgvpar
fsgsgsgtdysltissmepedaatyychqrgsxxytfgggtkleikrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
skadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7jicL (L:)
eivltqspaimsaspervtmtcsassgvnymhwyqqkpgtsprrwiydtsklasgvparf
sgsgsgtdysltissmpedaatyychqrgsytfgggtkleikrfppsdeqlksgtasvvc
llnfypreakvqwkvdnalqsgnsqesvteqdtyslsstltlskadyekhkvyacevthq
glsspvtksfnrge