PDB entry 7fic

View 7fic on RCSB PDB site
Description: Reversible lysine-targeted probes reveal residence time-based kinase selectivity in vivo
Class: cell cycle
Keywords: Reversible lysine-targeted inhibitors; kinase, CELL CYCLE
Deposited on 2021-07-31, released 2022-06-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-06-08, with a file datestamp of 2022-06-03.
Experiment type: XRAY
Resolution: 2.32 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aurora kinase A
    Species: Homo sapiens [TaxId:9606]
    Gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14965 (0-264)
      • engineered mutation (163)
    Domains in SCOPe 2.08: d7fica_
  • Heterogens: 5YZ, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ficA (A:)
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlagtldylppemiegrmh
dekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkh
npsqrpmlrevlehpwitansskps

    Sequence, based on observed residues (ATOM records): (download) 
    >7ficA (A:)
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadfgwsagtldylppemiegrmhdekvdlwslgv
lcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrev
lehpwitansskps