PDB entry 7fhs

View 7fhs on RCSB PDB site
Description: Crystal structure of DYRK1A in complex with RD0392
Class: transferase
Keywords: DYRK1A, Kinase, Inhibitor, TRANSFERASE
Deposited on 2021-07-30, released 2022-03-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-03-23, with a file datestamp of 2022-03-18.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (2-360)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7fhsa_
  • Chain 'B':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (2-360)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7fhsb_
  • Chain 'C':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (2-360)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7fhsc_
  • Chain 'D':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13627 (2-360)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7fhsd_
  • Heterogens: 4VZ, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7fhsA (A:)
gssshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqew
vaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsyn
lydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaik
ivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsga
nevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklh
nilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktad
e

    Sequence, based on observed residues (ATOM records): (download) 
    >7fhsA (A:)
kvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknk
kaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntn
frgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscq
lgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnki
vevlgippahildqapkarkffeklpdgtwnlkkteykppgtrklhnilgvetggpggrr
agesghtvadylkfkdlilrmldydpktriqpyyalqhsffkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7fhsB (B:)
gssshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqew
vaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsyn
lydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaik
ivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsga
nevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklh
nilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktad
e

    Sequence, based on observed residues (ATOM records): (download) 
    >7fhsB (B:)
kvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknk
kaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntn
frgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscq
lgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnki
vevlgippahildqapkarkffeklpdgtwnlkkeykppgtrklhnilgvetggpggrra
gesghtvadylkfkdlilrmldydpktriqpyyalqhsffkk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7fhsC (C:)
gssshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqew
vaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsyn
lydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaik
ivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsga
nevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklh
nilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktad
e

    Sequence, based on observed residues (ATOM records): (download) 
    >7fhsC (C:)
kvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknk
kaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntn
frgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscq
lgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnki
vevlgippahildqapkarkffeklpdgtwnlkkeykppgtrklhnilgvetggpggrra
gesghtvadylkfkdlilrmldydpktriqpyyalqhsffk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7fhsD (D:)
gssshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqew
vaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsyn
lydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaik
ivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsga
nevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklh
nilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktad
e

    Sequence, based on observed residues (ATOM records): (download) 
    >7fhsD (D:)
kvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknk
kaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntn
frgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscq
lgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnki
vevlgippahildqapkarkffeklpdgtwnlkkteykppgtrklhnilgvetggpggrr
agesghtvadylkfkdlilrmldydpktriqpyyalqhsffk