PDB entry 7f3g

View 7f3g on RCSB PDB site
Description: Crystal structure of DCLK1 kinase domain in complex with ruxolitinib
Class: signaling protein
Keywords: Doublecortin-like kinase 1, Kinase domain, Inhibitor, ruxolitinib, SIGNALING PROTEIN
Deposited on 2021-06-16, released 2021-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-08-18, with a file datestamp of 2021-08-13.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isoform 4 of Serine/threonine-protein kinase DCLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: DCLK1, DCAMKL1, DCDC3A, KIAA0369
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15075 (4-281)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d7f3ga_
  • Chain 'B':
    Compound: Isoform 4 of Serine/threonine-protein kinase DCLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: DCLK1, DCAMKL1, DCDC3A, KIAA0369
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15075 (4-281)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d7f3gb_
  • Heterogens: RXT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7f3gA (A:)
gamggeevseegfqipatiterykvgrtigdgnfavvkecverstareyalkiikkskcr
gkehmiqnevsilrrvkhpnivllieemdvptelylvmelvkggdlfdaitstnkyterd
asgmlynlasaikylhslnivhrdikpenllvyehqdgskslklgdfglativdgplytv
cgtptyvapeiiaetgyglkvdiwaagvityillcgfppfrgsgddqevlfdqilmgqvd
fpspywdnvsdsakelitmmllvdvdqrfsavqvlehpwvnd

    Sequence, based on observed residues (ATOM records): (download) 
    >7f3gA (A:)
seegfqipatiterykvgrtigdgnfavvkecverstareyalkiikkskcrgkehmiqn
evsilrrvkhpnivllieemdvptelylvmelvkggdlfdaitstnkyterdasgmlynl
asaikylhslnivhrdikpenllvyehqdgskslklgdfglativdgplytvcgtptyva
peiiaetgyglkvdiwaagvityillcgfppfrgsgddqevlfdqilmgqvdfpspywdn
vsdsakelitmmllvdvdqrfsavqvlehpwvn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7f3gB (B:)
gamggeevseegfqipatiterykvgrtigdgnfavvkecverstareyalkiikkskcr
gkehmiqnevsilrrvkhpnivllieemdvptelylvmelvkggdlfdaitstnkyterd
asgmlynlasaikylhslnivhrdikpenllvyehqdgskslklgdfglativdgplytv
cgtptyvapeiiaetgyglkvdiwaagvityillcgfppfrgsgddqevlfdqilmgqvd
fpspywdnvsdsakelitmmllvdvdqrfsavqvlehpwvnd

    Sequence, based on observed residues (ATOM records): (download) 
    >7f3gB (B:)
patiterykvgrtigdgnfavvkecverstareyalkiikkskcrgkehmiqnevsilrr
vkhpnivllieemdvptelylvmelvkggdlfdaitstnkyterdasgmlynlasaikyl
hslnivhrdikpenllvyehqdgskslklgdfglativdgplytvcgtptyvapeiiaet
gyglkvdiwaagvityillcgfppfrgsgddqevlfdqilmgqvdfpspywdnvsdsake
litmmllvdvdqrfsavqvlehpwvn